Targeted Cancer Treatment in Silico

Author: Natalia L. Komarova
Publisher: Springer Science & Business Media
ISBN: 1461483018
Format: PDF, ePub, Mobi
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Countless medical researchers over the past century have been occupied by the search for a cure of cancer. So far, they have developed and implemented a wide range of treatment techniques, including surgery, chemo- and radiotherapy, antiangiogenic drugs, small molecule inhibitors, and oncolytic viruses. However, patterns of these treatments' effectiveness remain largely unclear, and a better understanding of how cancer therapies work has become a key research goal. Cancer Treatment in Silico provides the first in-depth study of approaching this understanding by modeling cancer treatments, both mathematically and through computer simulations. The main goal of this book is to help expose students and researchers to in silico methods of studying cancer. It is intended for both the applied mathematics and experimental oncology communities, as mathematical models are playing an increasingly important role to supplement laboratory biology in the fight against cancer. Written at a level that generally requires little technical background, the work will be a valuable resource for scientists and students alike.

Computational Biology of Cancer

Author: Dominik Wodarz
Publisher: World Scientific
ISBN: 9814481874
Format: PDF, ePub, Docs
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' The book shows how mathematical and computational models can be used to study cancer biology. It introduces the concept of mathematical modeling and then applies it to a variety of topics in cancer biology. These include aspects of cancer initiation and progression, such as the somatic evolution of cells, genetic instability, and angiogenesis. The book also discusses the use of mathematical models for the analysis of therapeutic approaches such as chemotherapy, immunotherapy, and the use of oncolytic viruses. Contents:Cancer and Somatic EvolutionMathematical Modeling of TumorigenesisCancer Initiation: One-Hit and Two-Hit Stochastic ModelsMicrosatellite and Chromosomal Istability in Sporadic and Familial CancersCellular Origins of CancerCosts and Benefits of Chromosomal InstabilityDNA Damage and Genetic InstabilityTissue Aging and the Development of CancerBasic Models of Tumor Inhibition and PromotionMechanisms of Tumor NeovascularizationCancer and Immune ResponsesTherapeutic Approaches: Viruses as Anti-Tumor Weapons Readership: Researchers and academics in bioinformatics, biocomputing, biomathematics, cell/molecular biology and cancer biology, as well as clinicians. Keywords:Mathematics Models;Computational Biology;Cancer Initiation;Cancer Progression;Somatic Evolution;Genetic Instability;Therapy;Oncolytic VirusesKey Features:Provides an introduction to computational methods in cancer biologyFollows a multi-disciplinary approachReviews:“This book adds aspects not covered by other books and, therefore, represents a valuable addition to the literature about mathematical models in cancer biology.”Zentralblatt MATH '

Cancer New Insights for the Healthcare Professional 2011 Edition

Author:
Publisher: ScholarlyEditions
ISBN: 1464900027
Format: PDF, ePub, Mobi
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Cancer: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer. The editors have built Cancer: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cancer: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Dynamics of Cancer

Author: Dominik Wodarz
Publisher: World Scientific
ISBN: 9814566381
Format: PDF, Docs
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The book aims to provide an introduction to mathematical models that describe the dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for advanced undergraduate or graduate courses, and also serves as a reference book for researchers. The book has a strong evolutionary component and reflects the viewpoint that cancer can be understood rationally through a combination of mathematical and biological tools. It can be used both by mathematicians and biologists. Mathematically, the book starts with relatively simple ordinary differential equation models, and subsequently explores more complex stochastic and spatial models. Biologically, the book starts with explorations of the basic dynamics of tumor growth, including competitive interactions among cells, and subsequently moves on to the evolutionary dynamics of cancer cells, including scenarios of cancer initiation, progression, and treatment. The book finishes with a discussion of advanced topics, which describe how some of the mathematical concepts can be used to gain insights into a variety of questions, such as epigenetics, telomeres, gene therapy, and social interactions of cancer cells. Contents:Teaching GuideCancer and Somatic EvolutionMathematical Modeling of TumorigenesisBasic Growth Dynamics and Deterministic Models:Single Species GrowthTwo-Species Competition DynamicsCompetition Between Genetically Stable and Unstable CellsChromosomal Instability and Tumor GrowthAngiogenesis Inhibitors, Promoters, and Spatial GrowthEvolutionary Dynamics and Stochastic Models:Evolutionary Dynamics of Tumor Initiation Through Oncogenes: The Gain-of-Function ModelEvolutionary Dynamics of Tumor Initiation Through Tumor-Suppressor Genes: The Loss-of-Function Model and Stochastic TunnelingMicrosatellite and Chromosomal Instability in Sporadic and Familial Colorectal CancersEvolutionary Dynamics in Hierarchical PopulationsSpatial Evolutionary Dynamics of Tumor InitiationComplex Tumor Dynamics in SpaceStochastic Modeling of Cellular Growth, Treatment, and Resistance GenerationEvolutionary Dynamics of Drug Resistance in Chronic Myeloid LeukemiaAdvanced Topics:Evolutionary Dynamics of Stem-Cell Driven Tumor GrowthTumor Growth Kinetics and Disease ProgressionEpigenetic Changes and the Rate of DNA MethylationTelomeres and Cancer ProtectionGene Therapy and Oncolytic Virus TherapyImmune Responses, Tumor Growth, and TherapiesTowards Higher Complexities: Social Interactions Readership: Researchers in mathematical biology, mathematical modeling, biology, mathematical oncology. Keywords:Mathematical Oncology;Dynamics;Evolution;Evolutionary Dynamics;Cancer;Mathematical Models;Somatic Evolution;TeachingKey Features:Both a reference book for the topic, and provides material for undergraduate and graduate coursesTries to bridge the divide between mathematicians and biologists, which is also reflected in the backgrounds of the two authorsShows how mathematical concepts can be translated into experimentally and clinically useful insightsRooted in evolutionary biology, the book handles this very complex phenomenon in an intuitive and mathematically elegant wayContains problems and research projects for each topic10 pages of figures in color

Killer Cell Dynamics

Author: Dominik Wodarz
Publisher: Springer Science & Business Media
ISBN: 0387687335
Format: PDF, ePub, Docs
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This book reviews how mathematical and computational approaches can be useful to help us understand how killer T-cell responses work to fight viral infections. It also demonstrates, in a writing style that exemplifies the point, that such mathematical and computational approaches are most valuable when coupled with experimental work through interdisciplinary collaborations. Designed to be useful to immunoligists and viroligists without extensive computational background, the book covers a broad variety of topics, including both basic immunological questions and the application of these insights to the understanding and treatment of pathogenic human diseases.

The Spatial and Temporal Dynamics of Host Parasitoid Interactions

Author: Michael Hassell
Publisher: OUP Oxford
ISBN: 9780191588402
Format: PDF, Mobi
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This book examines our current understanding of the population dynamics of one kind of interaction - that between insect parasitoids and their hosts. Parasitoids are amongst the most abundant of all animals, and make up about 10% or more of metazoan species. Almost no insect species escape their attack. Host-parasitoid interactions were first modelled over fifty years ago, but for many years there was little good empirical information on the important factors that affect host and parasitoid populations. The models were very simple, and their predictions rather divorced from the complexity of what was visible in the field. Now, better data is available on many components of host-parasitoid systems, from field observations and laboratory and field experiments, and this allows a much closer correspondence between models and data. In particular, the past twenty years have seen major advances in our understanding of how host-parasitoid interactions are influenced by spatial processes, by age-structure effects, and by competition from additional host and parasitoid species. The result is a body of theory that makes direct contact with real systems in the field, and provides us with a detailed understanding of what underpins a whole area of population dynamics. In this book, Michael P Hassell pulls the theory and field data together to present an elegant illustration of the way in which ecological studies advance.

Modeling the Interplay Between Human Behavior and the Spread of Infectious Diseases

Author: Piero Manfredi
Publisher: Springer Science & Business Media
ISBN: 1461454743
Format: PDF, Kindle
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This volume summarizes the state-of-the-art in the fast growing research area of modeling the influence of information-driven human behavior on the spread and control of infectious diseases. In particular, it features the two main and inter-related “core” topics: behavioral changes in response to global threats, for example, pandemic influenza, and the pseudo-rational opposition to vaccines. In order to make realistic predictions, modelers need to go beyond classical mathematical epidemiology to take these dynamic effects into account. With contributions from experts in this field, the book fills a void in the literature. It goes beyond classical texts, yet preserves the rationale of many of them by sticking to the underlying biology without compromising on scientific rigor. Epidemiologists, theoretical biologists, biophysicists, applied mathematicians, and PhD students will benefit from this book. However, it is also written for Public Health professionals interested in understanding models, and to advanced undergraduate students, since it only requires a working knowledge of mathematical epidemiology.

Optimal Control for Mathematical Models of Cancer Therapies

Author: Heinz Schättler
Publisher: Springer
ISBN: 1493929720
Format: PDF, ePub, Docs
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This book presents applications of geometric optimal control to real life biomedical problems with an emphasis on cancer treatments. A number of mathematical models for both classical and novel cancer treatments are presented as optimal control problems with the goal of constructing optimal protocols. The power of geometric methods is illustrated with fully worked out complete global solutions to these mathematically challenging problems. Elaborate constructions of optimal controls and corresponding system responses provide great examples of applications of the tools of geometric optimal control and the outcomes aid the design of simpler, practically realizable suboptimal protocols. The book blends mathematical rigor with practically important topics in an easily readable tutorial style. Graduate students and researchers in science and engineering, particularly biomathematics and more mathematical aspects of biomedical engineering, would find this book particularly useful.

Novel Approaches and Strategies for Biologics Vaccines and Cancer Therapies

Author: Manmohan Singh
Publisher: Academic Press
ISBN: 012416661X
Format: PDF, Kindle
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Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies. Provides strategies for the development of safe and efficacious novel formulations for various modalities of biologics, vaccines and for cancer therapy Highlights novel cases from current clinical trials as well as marketed products Reviews overall successes and challenges in the development of novel formulations, including new molecular targets for the treatment of diseases, design of target-specific therapies, regulatory considerations, individualized therapies

Issues in Cancer Epidemiology and Research 2011 Edition

Author:
Publisher: ScholarlyEditions
ISBN: 1464963525
Format: PDF, ePub
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Issues in Cancer Epidemiology and Research / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer Epidemiology and Research. The editors have built Issues in Cancer Epidemiology and Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer Epidemiology and Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Cancer Epidemiology and Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.