Thalassaemia The Biography

Author: David Weatherall
Publisher: OUP Oxford
ISBN: 9780191614163
Format: PDF
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Thalassaemia is the most common type of genetic disorder in the human population, and one of the first whose genetic basis was established. Written by Sir David Weatherall, an expert in molecular medicine and the founder of the Institute of Molecular Medicine in Oxford, this tells the story of early reports of the disease, historical accounts, the identification of the disease as having an inherited basis, early work on thalassaemia as a disorder of the synthesis of haemoglobin, and from the 1960s with the rise of molecular biology, the study of the condition at the DNA level. The commonality of the disease raised an important evolutionary question: if thalassaemia is a genetic disorder then why hasn't it been selected out? Why does it persist, especially in Mediterranean populations? The great geneticist JBS Haldane suggested a reason - that carriers might be more resistant to malaria. Now that we have much more detailed understanding of the molecular basis of this set of diseases, has Haldane proved to be right? Weatherall shows that Haldane turns out to have been partially right. The book ends with recent improvements in treatment that have transformed patients' lives and a general assessment of how molecular approaches are impacting on medicine. Thalassaemia: the biography is part of the Oxford series, Biographies of Disease, edited by William and Helen Bynum. In each individual volume an expert historian of medicine tells the story of a particular disease or condition throughout history - not only in terms of growing medical understanding of its nature and cure, but also shifting social and cultural attitudes, and changes in the meaning of the name of the disease itself.

Cholera The Biography

Author: Christopher Hamlin
Publisher: Oxford University Press
ISBN: 019954624X
Format: PDF
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Cholera is a dangerous and frightening disease that can kill within hours. Chris Hamlin not only tells how the bacterial cause of cholera was discovered, but describes the experience of different countries, some of which continue to struggle with the disease today. Cholera is part of the Oxford series, Biographies of Diseases.

Thalassaemia The Biography

Author: David Weatherall
Publisher: Oxford University Press
ISBN: 0199565600
Format: PDF, Docs
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Presents a history of thalassemia, a genetic disorder in which the body destroys abnormally-shaped hemoglobin cells at a rate that leads to anemia.

Obesity The Biography

Author: Sander L. Gilman
Publisher: Oxford University Press
ISBN: 0199557977
Format: PDF, ePub
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A history of man's complex relationship with body weight explores its connections with social welfare, income, diet, and changing attitudes towards body image.

The Thalassaemia Syndromes

Author: David J. Weatherall
Publisher: John Wiley & Sons
ISBN: 0470695943
Format: PDF, ePub, Docs
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In the new edition of this successful and authoritative book, the thalassaemias are reviewed in detail with respect to their clinical features, cellular pathology, molecular genetics, prevention and treatment. It is aimed at specialists in haematology in the laboratory or clinical setting, particularly in areas where thalassaemia is common either in the native population or in immigrant communities. The fourth edition has been both updated and re-organized. Three new chapters have been added on the link between alpha-thalassaemia and mental retardation, on avoidance and population control and on global epidemiology. Considerable emphasis is placed on molecular pathology reflecting the huge burst of information to have come out of this field in the last few years.

Molecular Genetics of Thalassemia Syndromes

Author: Reena Das
Publisher: Biota Publishing
ISBN: 1615047255
Format: PDF, ePub, Docs
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This book reviews the molecular genetics of the thalassemia syndromes, inherited hemoglobin disorders that comprise the commonest monogenic disorders globally. Thalassemias are found in high frequencies in tropical regions corresponding to the malaria belt. Beta thalassemia traits show high HbA2 by HPLC, and β-globin mutations (commonly point mutations) are detected by using ARMS-PCR, reverse dot-blot analysis and β-globin gene sequencing. Globally >300 β globin gene mutations exist, however regional mutations are limited to 5-6 common ones. Alpha globin gene defects can only be identified by molecular tests, the exception being HbH disease that shows "golf ball" appearance in HbH preparation, pre-integration peaks on HPLC and a fast-moving band on hemoglobin electrophoresis. Multiplex Gap-PCR identifies common α-globin gene deletions. Specific PCR across the junction caused by the unequal crossing over can detect α-gene triplication. However, heterozygosity or homozygous triplication cannot be resolved by this technique. Non-deletional α-thalassemia can be characterized by specific α-globin gene sequencing. Identification of unusual deletions requires Multiplex Ligation-dependent Probe Amplification. In conclusion, the molecular characterization of human globin gene disorders is required to resolve the phenotypically heterogeneous thalassemia syndromes. Molecular analysis is also an important tool to prevent these disorders by offering prenatal screening in regions with a high disease burden.

Downs

Author: David Wright
Publisher: Oxford University Press
ISBN: 019956793X
Format: PDF, ePub, Docs
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Editorial Advisor, Helen Bynum is a freelancer historian and author. --Book Jacket.

Hysteria

Author: Andrew Scull
Publisher: Oxford University Press
ISBN: 019969298X
Format: PDF, ePub, Docs
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The story of hysteria is a curious one, for it persists as an illness for centuries before disappearing. Andrew Scull gives a fascinating account of this socially constructed disease that came to be strongly associated with women, showing the shifts in social, cultural, and medical perceptions through history.

The Economics of the Global Response to HIV AIDS

Author: Markus Haacker
Publisher: Oxford University Press
ISBN: 019102791X
Format: PDF
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The global response to HIV/AIDS has been a major aspect of global health and development policy over the last three decades. The book illustrates the devastating health impacts of the epidemic, with life expectancy in some countries falling to the lowest levels observed anywhere, and the remarkable success of the global HIV/AIDS response in reversing such extreme outcomes. Concerns about the implications of HIV/AIDS for economic development have played a role in motivating the global HIV/AIDS response. However, evidence on the impacts of HIV/AIDS on economic growth or poverty is weak, and the magnitude and relevance of such economic effects appears trivial compared to the consequences for life and health. Because of the success in extending access to treatment globally, HIV/AIDS has effectively transitioned into a chronic disease. This means that HIV/AIDS absorbs not only a substantial chunk of current global and national financial resources, but that these spending needs are projected to persist over decades. The costs of the HIV/AIDS response thus resemble a long-term financial liability, shaped by past and current policies. Relatedly, the calculus of cost-effectiveness of HIV/AIDS interventions has changed. People who become infected with HIV can now expect to not die because of AIDS; at the same time, each HIV infection results in medical needs and expenditures extending over decades. The book presents a framework for integrating these financial consequences and the transmission dynamics of HIV in the analysis of cost-effectiveness of HIV/AIDS interventions and in the design of HIV/AIDS programs.

Medical Encounters in British India

Author: Deepak Kumar
Publisher: OUP India
ISBN: 9780198089216
Format: PDF, Mobi
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This volume explores the nature of interactions between the East and the West in the field of medicine.It focuses on examples from India's medical tradition and the challenges it faced when modern medical system entered the country as part of the British colonial rule.