Thalassaemia The Biography

Author: David Weatherall
Publisher: OUP Oxford
ISBN: 9780191614163
Format: PDF, Docs
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Thalassaemia is the most common type of genetic disorder in the human population, and one of the first whose genetic basis was established. Written by Sir David Weatherall, an expert in molecular medicine and the founder of the Institute of Molecular Medicine in Oxford, this tells the story of early reports of the disease, historical accounts, the identification of the disease as having an inherited basis, early work on thalassaemia as a disorder of the synthesis of haemoglobin, and from the 1960s with the rise of molecular biology, the study of the condition at the DNA level. The commonality of the disease raised an important evolutionary question: if thalassaemia is a genetic disorder then why hasn't it been selected out? Why does it persist, especially in Mediterranean populations? The great geneticist JBS Haldane suggested a reason - that carriers might be more resistant to malaria. Now that we have much more detailed understanding of the molecular basis of this set of diseases, has Haldane proved to be right? Weatherall shows that Haldane turns out to have been partially right. The book ends with recent improvements in treatment that have transformed patients' lives and a general assessment of how molecular approaches are impacting on medicine. Thalassaemia: the biography is part of the Oxford series, Biographies of Disease, edited by William and Helen Bynum. In each individual volume an expert historian of medicine tells the story of a particular disease or condition throughout history - not only in terms of growing medical understanding of its nature and cure, but also shifting social and cultural attitudes, and changes in the meaning of the name of the disease itself.

Cholera The Biography

Author: Christopher Hamlin
Publisher: Oxford University Press
ISBN: 019954624X
Format: PDF, ePub, Docs
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Cholera is a dangerous and frightening disease that can kill within hours. Chris Hamlin not only tells how the bacterial cause of cholera was discovered, but describes the experience of different countries, some of which continue to struggle with the disease today. Cholera is part of the Oxford series, Biographies of Diseases.

Thalassaemia The Biography

Author: David Weatherall
Publisher: Oxford University Press
ISBN: 0199565600
Format: PDF, ePub, Docs
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Presents a history of thalassemia, a genetic disorder in which the body destroys abnormally-shaped hemoglobin cells at a rate that leads to anemia.

Social Research in Health and Illness

Author: Costas S. Constantinou
Publisher: Routledge
ISBN: 1317053524
Format: PDF, Docs
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Social Research in Health and Illness offers a theoretically informed guide to practising the key social research methods in investigating health and illness. Examining both methods and methodology, the authors explore the importance of selecting the appropriate research method for the project in question, demonstrating that researchers do not simply apply a set of neutral techniques to the issues that they investigate, but take part in a dynamic, reflective engagement with social and cultural worlds in a process of continual learning. With its application of a variety of research methods to concrete cases, this book provides a sociology of specific health conditions, thus rendering them more understandable, whilst clarifying the nature of research concepts, approaches, methods and methodologies by demonstrating their use in real-life settings. Drawing on case studies involving a range of health conditions, including mental illness, HIV, diabetes, kidney disease, Alzheimer’s disease, heart disease, breast cancer, thalassaemia and multiple sclerosis, the authors examine a range of methodological issues, exploring the use of focus groups, observation, data archives, interviews and surveys, while also considering questions of ethics and analysis. A comprehensive and practical examination of research methods in use in a defined field of social scientific enquiry, this volume is essential reading for scholars, graduate students and healthcare professionals with interests in conducting qualitative and quantitative research in the fields of health and medicine.

Medicine and Health Science

Author: Jon Turney
Publisher: Taylor & Francis
ISBN: 9781579583606
Format: PDF, Docs
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First Published in 2001. Routledge is an imprint of Taylor & Francis, an informa company.

The Politics of Sickle Cell and Thalassaemia

Author: Elizabeth N. Anionwu
Publisher:
ISBN:
Format: PDF, ePub
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"...a most interesting, eye-opening and often challenging book...it should be read by anyone involved in dealing with haemoglobinopathies, in the health or social care setting. Many others who are interested in the broader issues around chronic and particularly genetic disease will also find it stimulating reading." - Dr Anne Yardumian, Consultant Haematologist, North Middlesex Hospital, London "Overall this book acts as an invaluable introduction, acting as a template for considering chronic and genetic disease, and with its comprehensive bibliography should be a natural springboard for any practitioner wanting to develop their knowledge in this subject area." - Journal of Biosocial Science Sickle cell disorders and thalassaemia are inherited blood disorders. Sickle cell disorder alters the shape of the red blood cells from their usual round appearance to something which resembles a sickle, or half moon. Those born with thalassaemia major are unable to make a sufficient amount of haemoglobin. They will develop a fatal anaemia in early childhood if not treated with blood transfusion every four to six weeks, for life. Sickle cell disorders and thalassaemia are found mainly in families that come from Africa, South Asia, the Caribbean, the Eastern Mediterranean and the Middle East. There are estimated to be over 10,000 people with a sickle cell disorder (SCD) and around 600 cases of thalassaemia in the UK. Despite this high incidence, it is still an under researched topic, and a subject about which health professionals and policy makers know very little. After years of neglect, it is now attracting policy interest and there are new moves to improve existing provision. This timely book examines the politics of sickle cell and thalassaemia and offers a detailed evaluation of the services available. It is unusual in placing patients and their families at the centre of the study, allowing their views to be heard, and relating them to the delivery and organization of services. The problems that emerge range from inadequate language support, inappropriate generalizations, poor quality care, as well as institutional and individual racism. The book also identifies models of good practice and suggests ways in which we can learn from these. General policy and practice issues are highlighted throughout, and the need for a more systematic approach to planning and providing culturally sensitive services is addressed.

The Handbook of Genetics Society

Author: Paul Atkinson
Publisher: Routledge
ISBN: 1134128770
Format: PDF, ePub, Mobi
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An authoritative Handbook which offers a discussion of the social, political, ethical and economic consequences and implications of the new bio-sciences. The Handbook takes an interdisciplinary approach providing a synoptic overview of contemporary international social science research on genetics, genomics and the new life sciences. It brings together leading scholars with expertise across a wide-ranging spectrum of research fields related to the production, use, commercialisation and regulation of genetics knowledge. The Handbook is structured into seven cross-cutting themes in contemporary social science research on genetics with introductions written by internationally renowned section editors who take an interdisciplinary approach to offer fresh insights on recent developments and issues in often controversial fields of study. The Handbook explores local and global issues and critically approaches a wide range of public and policy questions, providing an invaluable reference source to a wide variety of researchers, academics and policy makers.