The Gradient Test

Author: Artur Lemonte
Publisher: Academic Press
ISBN: 0128036133
Format: PDF, Docs
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The Gradient Test: Another Likelihood-Based Test presents the latest on the gradient test, a large-sample test that was introduced in statistics literature by George R. Terrell in 2002. The test has been studied by several authors, is simply computed, and can be an interesting alternative to the classical large-sample tests, namely, the likelihood ratio (LR), Wald (W), and Rao score (S) tests. Due to the large literature about the LR, W and S tests, the gradient test is not frequently used to test hypothesis. The book covers topics on the local power of the gradient test, the Bartlett-corrected gradient statistic, the gradient statistic under model misspecification, and the robust gradient-type bounded-influence test. Covers the background of the gradient statistic and the different models Discusses The Bartlett-corrected gradient statistic Explains the algorithm to compute the gradient-type statistic

Statistical Advances in the Biomedical Sciences

Author: Atanu Biswas
Publisher: John Wiley & Sons
ISBN: 9780470181195
Format: PDF, ePub, Docs
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The Most Comprehensive and Cutting-Edge Guide to Statistical Applications in Biomedical Research With the increasing use of biotechnology in medical research and the sophisticated advances in computing, it has become essential for practitioners in the biomedical sciences to be fully educated on the role statistics plays in ensuring the accurate analysis of research findings. Statistical Advances in the Biomedical Sciences explores the growing value of statistical knowledge in the management and comprehension of medical research and, more specifically, provides an accessible introduction to the contemporary methodologies used to understand complex problems in the four major areas of modern-day biomedical science: clinical trials, epidemiology, survival analysis, and bioinformatics. Composed of contributions from eminent researchers in the field, this volume discusses the application of statistical techniques to various aspects of modern medical research and illustrates how these methods ultimately prove to be an indispensable part of proper data collection and analysis. A structural uniformity is maintained across all chapters, each beginning with an introduction that discusses general concepts and the biomedical problem under focus and is followed by specific details on the associated methods, algorithms, and applications. In addition, each chapter provides a summary of the main ideas and offers a concluding remarks section that presents novel ideas, approaches, and challenges for future research. Complete with detailed references and insight on the future directions of biomedical research, Statistical Advances in the Biomedical Sciences provides vital statistical guidance to practitioners in the biomedical sciences while also introducing statisticians to new, multidisciplinary frontiers of application. This text is an excellent reference for graduate- and PhD-level courses in various areas of biostatistics and the medical sciences and also serves as a valuable tool for medical researchers, statisticians, public health professionals, and biostatisticians.

Clinical Tests of Respiratory Function 3rd Edition

Author: G John Gibson
Publisher: CRC Press
ISBN: 1444109634
Format: PDF, ePub, Docs
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Already established as a 'classic' in the field, Clinical Tests of Respiratory Function presents an authoritative yet accessible account of this complex area, fusing the basic principles of respiratory physiology with applications in clinical practice across a wide range of disorders. This third edition has been extensively revised to reflect advances in our understanding of respiratory function at rest, on exercise and during sleep, together with technological developments related to investigation and treatment. Now subdivided into four practical sections, users can easily pick their desired topic, from the commonly used tests and their underlying physiological mechanisms to abnormalities of function in both respiratory and non-respiratory diseases. The book concludes with a helpful section on test interpretation, new to this edition. This eagerly awaited revision will quickly find a place on the bookshelves of all practitioners - clinicians and laboratory investigators - who have an interest in respiratory function. From the reviews of the second edition: 'skillfull achieves lucid descriptions of complex physiological concepts ..... a classsic within the pulmonary literature, providing a concise yet complete account of pulmonary physiology from a clinical perspective' British Journal of Hospital Medicine 'very useful...the book is authoritative, comprehensive, extensively referenced and - for a book on this topic - easy to read and understand' Thorax

Microeconometrics

Author: A. Colin Cameron
Publisher: Cambridge University Press
ISBN: 9780521848053
Format: PDF
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This text is the most comprehensive work to date on microeconometrics, its methods and applications.

Econometric Methods with Applications in Business and Economics

Author: Christiaan Heij
Publisher: OUP Oxford
ISBN: 0191608408
Format: PDF, ePub
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Nowadays applied work in business and economics requires a solid understanding of econometric methods to support decision-making. Combining a solid exposition of econometric methods with an application-oriented approach, this rigorous textbook provides students with a working understanding and hands-on experience of current econometrics. Taking a 'learning by doing' approach, it covers basic econometric methods (statistics, simple and multiple regression, nonlinear regression, maximum likelihood, and generalized method of moments), and addresses the creative process of model building with due attention to diagnostic testing and model improvement. Its last part is devoted to two major application areas: the econometrics of choice data (logit and probit, multinomial and ordered choice, truncated and censored data, and duration data) and the econometrics of time series data (univariate time series, trends, volatility, vector autoregressions, and a brief discussion of SUR models, panel data, and simultaneous equations). · Real-world text examples and practical exercise questions stimulate active learning and show how econometrics can solve practical questions in modern business and economic management. · Focuses on the core of econometrics, regression, and covers two major advanced topics, choice data with applications in marketing and micro-economics, and time series data with applications in finance and macro-economics. · Learning-support features include concise, manageable sections of text, frequent cross-references to related and background material, summaries, computational schemes, keyword lists, suggested further reading, exercise sets, and online data sets and solutions. · Derivations and theory exercises are clearly marked for students in advanced courses. This textbook is perfect for advanced undergraduate students, new graduate students, and applied researchers in econometrics, business, and economics, and for researchers in other fields that draw on modern applied econometrics.

Statistical Models in Epidemiology

Author: David Clayton
Publisher: OUP Oxford
ISBN: 0191650919
Format: PDF, ePub, Docs
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This self-contained account of the statistical basis of epidemiology has been written specifically for those with a basic training in biology, therefore no previous knowledge is assumed and the mathematics is deliberately kept at a manageable level. The authors show how all statistical analysis of data is based on probability models, and once one understands the model, analysis follows easily. In showing how to use models in epidemiology the authors have chosen to emphasize the role of likelihood, an approach to statistics which is both simple and intuitively satisfying. More complex problems can then be tackled by natural extensions of the simple methods. Based on a highly successful course, this book explains the essential statistics for all epidemiologists.

The Hippocampus Book

Author: Per Andersen
Publisher: Oxford University Press
ISBN: 0199880131
Format: PDF, ePub, Mobi
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The hippocampus is one of a group of remarkable structures embedded within the brain's medial temporal lobe. Long known to be important for memory, it has been a prime focus of neuroscience research for many years. The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists knowledgeable about hippocampal anatomy, physiology, and function. This authoritative volume offers the most comprehensive, up-to-date account of what the hippocampus does, how it does it, and what happens when things go wrong. At the same time, it illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, synaptic plasticity, cognition and behavior, and computational algorithms. Well-organized in its presentation of both theory and experimental data, this peerless work vividly illustrates the astonishing progress that has been made in unraveling the workings of the brain. The Hippocampus Book is destined to take a central place on every neuroscientist's bookshelf.

Textbook of Adult Emergency Medicine

Author: Peter Cameron
Publisher: Elsevier Health Sciences
ISBN: 0702054380
Format: PDF
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Now fully revised and updated, Textbook of Adult Emergency Medicine provides clear and consistent coverage of this rapidly evolving specialty. Building on the success of previous editions, it covers all the major topics that present to the trainee doctor in the emergency department. It will also prove invaluable to the range of other professionals working in this setting - including nurse specialists and paramedics - who require concise, highly practical guidance, incorporating latest best practices and current guidelines. For the first time, this edition now comes with access to addtional ancillary meterial, including practical procdure videos and self-assessment material. Updates throughout reflect latest practice developments, curricula requirements and essential guidelines Key point boxes highlight topic ‘essentials’ as well as controversial areas of treatment An expanded list of leading international contributors ensures comprehensive coverage and maximizes worldwide relevance New and enhanced coverage of important and topical areas - including latest imaging in emergency medicine; organ donation; massive transfusion protocols; medico legal issues; patient safety and quality measures All new accompanying electronic ancillariy material, including procedure videos and self-assessment materials to check your understanding and aid exam preparation Expansion of administration section - especially patient safety New and enhanced coverage of important and topical areas - including latest imaging in emergency medicine; organ donation; massive transfusion protocols; medico legal issues; patient safety and quality measures All new accompanying electronic ancillary materials - including practical procedures videos and self-assessment materials

Valvular Heart Disease A Companion to Braunwald s Heart Disease E Book

Author: Catherine M. Otto
Publisher: Elsevier Health Sciences
ISBN: 1437721478
Format: PDF, ePub, Docs
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Valvular Heart Disease is now an even better source for all your questions on dysfunctions or abnormalities of the heart’s four valves. In the third edition, Catherine Otto is joined by Robert Bonow and a team of expert contributors to bring you the latest developments in imaging and treatment. The full-color images and illustrations reflect the cutting-edge imaging and diagnostic modalities—Doppler echo and MR—that are so important for diagnosing aortic valve defects. Superb diagrams, an increased focus on imaging and case-based presentation, and new chapters—on Cardiac MR and CT imaging for valvular heart disease; Genetic, molecular and cellular mechanisms of valvular disease; Bicuspid aortic valve disease; and Ischemic mitral regurgitation—further enhance this valuable reference. Presents comprehensive coverage of valvular heart disease to provide you with a complete reference and one-stop shop for this specialty in cardiac medicine. Provides complete guidance on how and why to surgically treat valve patients for a reliable manual on managing difficult cases. Features chapters on pediatric and pregnant patients so you know what considerations to take into account when treating these special populations. Introduces Robert Bonow as an editor, who joins Catherine Otto and the team of expert authors to provide you with guidance from leaders in the field. Features new chapters—Genetic, molecular and cellular mechanisms of valvular disease; Bicuspid aortic valve disease; and Ischemic mitral regurgitation—for the latest in cutting-edge research and clinical data. Reflects the latest in imaging modalities in the new section on cardiac MR and CT imaging for valvular heart disease to provide you with a full understand of the tools for the most accurate diagnosis. Presents detailed illustrations and images in full color to better showcase valve anatomy and dysfunction, as well as important techniques and surgical procedures. Includes a summary of the new ACC/AHA valvular heart disease guidelines in each chapter to keep you up to date on the latest best practices throughout the field.

Probabilistic Graphical Models for Genetics Genomics and Postgenomics

Author: Raphaël Mourad
Publisher: OUP Oxford
ISBN: 0191019208
Format: PDF, ePub
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Nowadays bioinformaticians and geneticists are faced with myriad high-throughput data usually presenting the characteristics of uncertainty, high dimensionality and large complexity. These data will only allow insights into this wealth of so-called 'omics' data if represented by flexible and scalable models, prior to any further analysis. At the interface between statistics and machine learning, probabilistic graphical models (PGMs) represent a powerful formalism to discover complex networks of relations. These models are also amenable to incorporating a priori biological information. Network reconstruction from gene expression data represents perhaps the most emblematic area of research where PGMs have been successfully applied. However these models have also created renewed interest in genetics in the broad sense, in particular regarding association genetics, causality discovery, prediction of outcomes, detection of copy number variations, and epigenetics. This book provides an overview of the applications of PGMs to genetics, genomics and postgenomics to meet this increased interest. A salient feature of bioinformatics, interdisciplinarity, reaches its limit when an intricate cooperation between domain specialists is requested. Currently, few people are specialists in the design of advanced methods using probabilistic graphical models for postgenomics or genetics. This book deciphers such models so that their perceived difficulty no longer hinders their use and focuses on fifteen illustrations showing the mechanisms behind the models. Probabilistic Graphical Models for Genetics, Genomics and Postgenomics covers six main themes: (1) Gene network inference (2) Causality discovery (3) Association genetics (4) Epigenetics (5) Detection of copy number variations (6) Prediction of outcomes from high-dimensional genomic data. Written by leading international experts, this is a collection of the most advanced work at the crossroads of probabilistic graphical models and genetics, genomics, and postgenomics. The self-contained chapters provide an enlightened account of the pros and cons of applying these powerful techniques.