The Handbook of Neuropsychiatric Biomarkers Endophenotypes and Genes

Author: Michael Ritsner
Publisher: Springer Science & Business Media
ISBN: 1402094647
Format: PDF, Mobi
Download Now
Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer’s disease, epilepsy, alcoholism, substance abuse and others are some of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunity to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances. This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry. The book is organized into four interconnected volumes: “Neuropsychological Endophenotypes and Biomarkers” (with overview of methodological issues of the biomarker and endophenotype approaches in neuropsychiatry and some technological advances), “Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers”, “Metabolic and Peripheral Biomarkers” and “Molecular Genetic and Genomic Markers”. The contributors are internationally and nationally recognized researchers and experts from 16 countries. This four-volume handbook is intended for a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, health care providers in the field of neurology and mental health interested in trends that have crystallized in the last decade, and trends that can be expected to further evolve in the coming years. It is hoped that this book will also be a useful resource for the teaching of psychiatry, neurology, psychology and mental health.

Handbook of Schizophrenia Spectrum Disorders Volume II

Author: Michael S. Ritsner
Publisher: Springer Science & Business Media
ISBN: 9789400708310
Format: PDF, Docs
Download Now
A few disorders have some of the same symptoms as schizophrenia including schizoaffective disorders, schizophreniform disorder, schizotypal and schizoid personality disorders, delusional disorder, and autism (schizophrenia spectrum disorders). Since the 2000 there has been significant progress in our understanding of the early presentations, assessment, suspected neuropathology, and treatment of these disorders. Recent technological breakthroughs in basic sciences hold promise for advancing our understanding of the pathophysiology of schizophrenia spectrum disorders. This collective monograph reviewers recent researches regarding the origins, onset, course, and outcome of schizophrenia spectrum disorders. In particular, this book will be illustrate new developments in terms of conceptual models, and research methodology, genetics and genomics, brain imaging and neurochemical studies, neurophysiology and information processing in schizophrenia spectrum disorders patients. Also will be highlighted new developments in our understanding of the childhood psychosis, prodromal and first-episode states, in treatment and rehabilitation. Thus, the purpose of this book is to provide up-to-date overview of the rapid advances made in the clinical and basic science studies supporting our understanding of the relationship between cerebral processes and clinical, cognitive and other presentations of the schizophrenia spectrum disorders. In addition, this book aims to monitor important research developments, which may be relevant to treatment, and rehabilitation of patients.

A Life Course Approach to Mental Disorders

Author: Karestan C. Koenen
Publisher: OUP Oxford
ISBN: 0191631167
Format: PDF, ePub, Mobi
Download Now
A Life Course Approach to Mental Disorders examines the interplay of social and biological factors in the production of a wide range of mental disorders throughout life, from the peri-natal period through to old age. The aging into adulthood of numerous birth cohorts, especially over the past twenty years, has provided increasing evidence that mental disorders previously perceived to emerge in adulthood may have their origins early in life. This book brings together, in a single resource, the research in life course epidemiology of mental disorders, forging a consensus on the current science and pointing the way forward for the field. Assembling researchers across disparate disciplines including epidemiology, developmental psychopathology, psychiatric genetics, sociology, developmental cognitive neuroscience, and epigenetics the book reviews the methods and synthesizes existing knowledge about the life course epidemiology of mental disorders in populations. It also presents discussions of the mechanisms that drive the production of mental disorders over the life course including emerging areas of research in the field. A Life Course Approach to Mental Disorders brings together the state-of-the-art science of life course epidemiology to inform training, research, practice and policy with regard to mental disorders. The first comprehensive articulation of a life course perspective in the area, it will be a key resource for academics, researchers and students.

The Handbook of Biomarkers

Author: Kewal K. Jain
Publisher: Humana Press
ISBN: 1493974319
Format: PDF, Kindle
Download Now
Involved in nearly every therapeutic area, particularly cancer, biomarkers have experienced tremendous advances since the first edition of this book, both in the discovery of biomarkers and in their applications. To aid in this imperative research, Prof. Kewal K. Jain’s Handbook of Biomarkers, Second Edition features a full revision and additional chapters to thoroughly describe many different types of biomarkers and their discovery using various "-omics" technologies, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers, Second Edition serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important trends in healthcare today.

Modeling the Psychopathological Dimensions of Schizophrenia

Author: Mikhail Pletnikov
Publisher: Academic Press
ISBN: 012801184X
Format: PDF, Docs
Download Now
Modeling the Psychopathological Dimensions of Schizophrenia: From Molecules to Behavior is the first book to offer a comprehensive review of the new theoretical, clinical, and basic research framework that considers psychotic illness as a group of dimensional representations of psychopathology rather than as traditional distinct categorical diagnoses. Psychotic illness, typified by schizophrenia, is a devastating condition increasingly recognized as a disorder of abnormal brain development and dysconnectivity. Its complex etiology involves both genetic and environmental factors, as well as the interplay among them. This book describes the current understanding of the clinical and pathological features of schizophrenia, with a particular focus on the evolving conceptualization of schizophrenia and related diagnostic categories of psychotic illness as combinations of dimensional abnormalities. It provides an overview of modern strategies for generating cellular and whole animal models of schizophrenia as well as detailed reviews of the specific experimental preparations and paradigms aimed at molecular, developmental, and brain-network mechanisms that are the underlying aspects of abnormal behavior and various aspects of schizophrenia. This groundbreaking book is an authoritative overview of the translational impact of emerging clinical insights on basic research approaches in schizophrenia that will advance the reader’s understanding of the five major dimensions of psychopathology in schizophrenia and related psychoses and resolve the genetic and neurobiological underpinnings of these dimensions. Includes reviews of animal models that capture the most recent insights into the etiology and pathogenetic mechanisms of schizophrenia, with an emphasis on the translational potential of these models Contains a series of reviews of recently available cellular models for analysis of signaling pathways and gene expression, which complement behavioral neuroscience research in schizophrenia Edited and authored by leading researchers in the field of schizophrenia and related psychoses

Handbook of Schizophrenia Spectrum Disorders Volume I

Author: Michael S Ritsner
Publisher: Springer Science & Business Media
ISBN: 9789400708372
Format: PDF, Kindle
Download Now
A few disorders have some of the same symptoms as schizophrenia including schizoaffective disorders, schizophreniform disorder, schizotypal and schizoid personality disorders, delusional disorder, and autism (schizophrenia spectrum disorders). Since the 2000 there has been significant progress in our understanding of the early presentations, assessment, suspected neuropathology, and treatment of these disorders. Recent technological breakthroughs in basic sciences hold promise for advancing our understanding of the pathophysiology of schizophrenia spectrum disorders. This collective monograph reviewers recent researches regarding the origins, onset, course, and outcome of schizophrenia spectrum disorders. In particular, this book will be illustrate new developments in terms of conceptual models, and research methodology, genetics and genomics, brain imaging and neurochemical studies, neurophysiology and information processing in schizophrenia spectrum disorders patients. Also will be highlighted new developments in our understanding of the childhood psychosis, prodromal and first-episode states, in treatment and rehabilitation. Thus, the purpose of this book is to provide up-to-date overview of the rapid advances made in the clinical and basic science studies supporting our understanding of the relationship between cerebral processes and clinical, cognitive and other presentations of the schizophrenia spectrum disorders. In addition, this book aims to monitor important research developments, which may be relevant to treatment, and rehabilitation of patients.

Anatomic Basis of Neurologic Diagnosis

Author: Cary D. Alberstone
Publisher: Thieme
ISBN: 1604061693
Format: PDF, Kindle
Download Now
2010 Benjamin Franklin Silver Award Winner!Praise for this book:Superbly written...Each anatomic structure is discussed in detail, yet the language is concise and not overwhelming...accompanied by impressive color illustrations that are extensive and original...the perfect resource.--AANS (American Association of Neurological Surgeons) Young Neurosurgeons' NewsletterAnatomic Basis of Neurologic Diagnosis is a lavishly illustrated book that places special emphasis on the paramount importance of signs and symptoms for the accurate diagnosis of neurologic disorders. It opens with a comprehensive review of neuroembryology, enabling readers to gain knowledge of normal nervous system development and related developmental disorders. The second section of the book comprises an easily accessible presentation of the anatomy of regional parts and to-the-point information on the cardinal manifestations of disease. Separate chapters in the third section of the book present the anatomy of different functional systems and provide practical approaches to diagnosing patients with system disorders. A final chapter covers the anatomy of the vascular system and cerebrospinal fluid. Highlights: Practical organization of chapters, according to regions and functional systems, reflects the clinician's approach to patient care Full-color illustrations provide an indispensable visual aid to learning and reviewing clinically relevant neurologic anatomy and pathways Numerous tables summarize key points Ideal for reading cover-to-cover, this book is essential for residents and students seeking to fully understand the complexity of clinical neuroanatomy. Seasoned clinicians will find the book a valuable refresher.

Textbook of Psychiatric Epidemiology

Author: Ming T. Tsuang
Publisher: John Wiley & Sons
ISBN: 047097740X
Format: PDF, Kindle
Download Now
The new edition of this critically praised textbook continues to provide the most comprehensive overview of the concepts, methods, and research advances in the field; particularly the application of molecular genomics and of neuroimaging. It has been revised and enhanced to capitalize on the strengths of the first and second editions while keeping it up-to-date with the field of psychiatry and epidemiology. This comprehensive publication now includes chapters on experimental epidemiology, gene-environment interactions, the use of case registries, eating disorders, suicide, childhood disorders and immigrant populations, and the epidemiology of a number of childhood disorders. As in the first and second editions, the objective is to provide a comprehensive, easy to understand overview of research methods for the non-specialist. The book is ideal for students of psychiatric epidemiology, psychiatric residents, general psychiatrists, and other mental health professionals. The book features a new editor, Peter Jones, from the University of Cambridge, who joins the successful US team of Ming Tsuang and Mauricio Tohen.

Brain Protection in Schizophrenia Mood and Cognitive Disorders

Author: Michael S. Ritsner
Publisher: Springer Science & Business Media
ISBN: 9789048185535
Format: PDF
Download Now
Neuroprotection is a novel perspective for the treatment of disorders that lead to neurodegeneration and disabilities as a result of deterioration of neurons due to apoptosis, oxidative stress, excitotoxicity, and other mechanisms. These mechanisms have implications not only for neurodegenerative disorders, but also for schizophrenia, mood and cognitive disorders. The purpose of this book is to provide an up-to-date overview of basic and clinical studies concerning the neuroprotective approach, mechanisms, and several compounds with neuroprotective properties that may contribute to more efficacious treatment of major mental health disorders. The book is divided into two sections. The first section serves as an introduction and overview of conceptual issues of the neuroprotective approach, and some neurobiological advances. Chapters in this section review definitions, perspectives, and issues that provide a conceptual base for the rest of the book. In addition, this part includes chapters in which the authors present and discuss the findings from basic studies of neurodegenerative mechanisms that are associated with the pathogenesis of major mental health disorders. The second section focuses on findings obtained from clinical trials with neuroprotective compounds, and neuromodulatory techniques. The take-home message is that principles of the neuroprotective approach may be applied to treatment of schizophrenia, mood and cognitive disorders. Contributors to this book are among the most active investigators and clinicians in the field who provide new perspectives not only clarifying ongoing controversies but also propose diverse aspects and new insights to neuroprotection. This book is intended for a broad readership, which includes a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, graduate students, and policy makers in the fields of mental health.

Behavioral Genetics

Author: Robert Plomin
Publisher: Macmillan Higher Education
ISBN: 1464148457
Format: PDF, ePub
Download Now
For over four decades, Behavioral Genetics has explored the crossroads where psychology and genetics meet, advancing step by step with this dynamic area of research as new discoveries emerge. The new Sixth Edition takes its place as the clearest, most up-to-date overview of human and animal behavioral genetics available, introducing students to the field’s underlying principles, defining experiments, recent advances, and ongoing controversies.