The Handbook of Neuropsychiatric Biomarkers Endophenotypes and Genes

Author: Michael Ritsner
Publisher: Springer Science & Business Media
ISBN: 1402094647
Format: PDF, ePub, Docs
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Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer’s disease, epilepsy, alcoholism, substance abuse and others are some of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunity to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances. This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry. The book is organized into four interconnected volumes: “Neuropsychological Endophenotypes and Biomarkers” (with overview of methodological issues of the biomarker and endophenotype approaches in neuropsychiatry and some technological advances), “Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers”, “Metabolic and Peripheral Biomarkers” and “Molecular Genetic and Genomic Markers”. The contributors are internationally and nationally recognized researchers and experts from 16 countries. This four-volume handbook is intended for a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, health care providers in the field of neurology and mental health interested in trends that have crystallized in the last decade, and trends that can be expected to further evolve in the coming years. It is hoped that this book will also be a useful resource for the teaching of psychiatry, neurology, psychology and mental health.

Handbook of Schizophrenia Spectrum Disorders Volume II

Author: Michael S. Ritsner
Publisher: Springer Science & Business Media
ISBN: 9789400708310
Format: PDF, ePub
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A few disorders have some of the same symptoms as schizophrenia including schizoaffective disorders, schizophreniform disorder, schizotypal and schizoid personality disorders, delusional disorder, and autism (schizophrenia spectrum disorders). Since the 2000 there has been significant progress in our understanding of the early presentations, assessment, suspected neuropathology, and treatment of these disorders. Recent technological breakthroughs in basic sciences hold promise for advancing our understanding of the pathophysiology of schizophrenia spectrum disorders. This collective monograph reviewers recent researches regarding the origins, onset, course, and outcome of schizophrenia spectrum disorders. In particular, this book will be illustrate new developments in terms of conceptual models, and research methodology, genetics and genomics, brain imaging and neurochemical studies, neurophysiology and information processing in schizophrenia spectrum disorders patients. Also will be highlighted new developments in our understanding of the childhood psychosis, prodromal and first-episode states, in treatment and rehabilitation. Thus, the purpose of this book is to provide up-to-date overview of the rapid advances made in the clinical and basic science studies supporting our understanding of the relationship between cerebral processes and clinical, cognitive and other presentations of the schizophrenia spectrum disorders. In addition, this book aims to monitor important research developments, which may be relevant to treatment, and rehabilitation of patients.

A Life Course Approach to Mental Disorders

Author: Karestan C. Koenen
Publisher: OUP Oxford
ISBN: 0191631167
Format: PDF
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A Life Course Approach to Mental Disorders examines the interplay of social and biological factors in the production of a wide range of mental disorders throughout life, from the peri-natal period through to old age. The aging into adulthood of numerous birth cohorts, especially over the past twenty years, has provided increasing evidence that mental disorders previously perceived to emerge in adulthood may have their origins early in life. This book brings together, in a single resource, the research in life course epidemiology of mental disorders, forging a consensus on the current science and pointing the way forward for the field. Assembling researchers across disparate disciplines including epidemiology, developmental psychopathology, psychiatric genetics, sociology, developmental cognitive neuroscience, and epigenetics the book reviews the methods and synthesizes existing knowledge about the life course epidemiology of mental disorders in populations. It also presents discussions of the mechanisms that drive the production of mental disorders over the life course including emerging areas of research in the field. A Life Course Approach to Mental Disorders brings together the state-of-the-art science of life course epidemiology to inform training, research, practice and policy with regard to mental disorders. The first comprehensive articulation of a life course perspective in the area, it will be a key resource for academics, researchers and students.

Textbook of Psychiatric Epidemiology

Author: Ming T. Tsuang
Publisher: John Wiley & Sons
ISBN: 047097740X
Format: PDF, ePub
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The new edition of this critically praised textbook continues to provide the most comprehensive overview of the concepts, methods, and research advances in the field; particularly the application of molecular genomics and of neuroimaging. It has been revised and enhanced to capitalize on the strengths of the first and second editions while keeping it up-to-date with the field of psychiatry and epidemiology. This comprehensive publication now includes chapters on experimental epidemiology, gene-environment interactions, the use of case registries, eating disorders, suicide, childhood disorders and immigrant populations, and the epidemiology of a number of childhood disorders. As in the first and second editions, the objective is to provide a comprehensive, easy to understand overview of research methods for the non-specialist. The book is ideal for students of psychiatric epidemiology, psychiatric residents, general psychiatrists, and other mental health professionals. The book features a new editor, Peter Jones, from the University of Cambridge, who joins the successful US team of Ming Tsuang and Mauricio Tohen.

Quality of Life Deficit in Mental Disorders

Author: Michael S. Ritsner
Publisher: Springer
ISBN: 9783319405445
Format: PDF, ePub
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Going beyond the psychosocial aspects of quality of life and delving into the neurobiological basis of emotions, feelings and satisfaction, this unique title provides a state-of-the-art overview of subjective quality of life for people with severe mental disorders such as schizophrenia, schizoaffective disorders, major depressive disorder and bipolar disorder (mood disorders). Four crucial issues are addressed: the main characteristics of the quality of life deficit in individuals with severe mental disorders; the course of quality of life deficits among these patients; the underlying factors (indicators and predictors) that influence quality of life; and a suitable model that can help interpret the findings of quality of life research and treatment interventions. Answering these questions, the book provides an overview of the currently available publications and contains a detailed analysis of quality of life and related variables from the Sha’ar Menashe Longitudinal Naturalistic Quality of Life Study (SMQOL). The Distress/Protection Vulnerability Quality of Life Model was applied in order to assist the reader in understanding empirical findings. With twenty-three chapters organized in four sections, this comprehensive and novel reference will be of great interest to a broad spectrum of readers including psychiatrists, psychologists, neurologists, neuroscientists, pharmacologists, general practitioners, geriatricians, graduate students, researchers, health care providers and policy makers in the fields of mental health and rehabilitation.

Psychiatrische Perspektiven

Author: Paul R. McHugh
Publisher: Springer
ISBN: 9783642709234
Format: PDF, ePub, Mobi
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stematiker apostrophiert, deren Leistungen bestenfalls als überholt angese hen werden, nicht selten jedoch auch als Hemmschuh für die neuen Seh weisen einer psychodynamischen Psychiatrie mit tiefen psychologischen Theorien, Lehranalysen, Selbsterfahrungsgruppen u. a. m. Unberücksichtigt bleibt dabei meist, daß viele der neuen Lehren trotz der Betonung von Be griffen wie "Seele" oder "psychisch" im Grunde nur maskierte Formen einer modischen identitätstheoretischen Philosophie materialistischer Couleur darstellen (Koehler 1984). Gewiß ist gegen eine psychodynamische Ausbildung des psychiatri schen Nachwuchses wenig einzuwenden, sofern eine Verabsolutierung des gewählten Standpunktes vermieden wird. Leider stellen die zweifellos erfor derlichen tiefen psychologischen Aspekte noch keinen selbstverständlichen Teil einer integralen psychiatrischen Ausbildung an den deutschen Klini ken dar, in denen der junge Assistenzarzt sein diagnostisches und therapeu tisches Wissen erwirbt (Mombour 1984). Deshalb sieht er sich fast überall gezwungen, unter zum Teil erheblichen Schwierigkeiten seinen Zusatztitel für Psychotherapie "außer Haus" zu erwerben. Dessen schwere Zugäng lichkeit, die vor allem institutionell bedingt ist, mag zur Tendenz beitragen, daß die psychodynamische Sehweise eine herausgehobene Position erhält und in der Vorstellung gerade der psychiatrischen Anfanger leicht zum do minierenden Denkansatz gerät.

Erblichkeit und Nervenleiden

Author: F. Kehrer
Publisher: Springer-Verlag
ISBN: 3642908055
Format: PDF
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Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.