The Mold in Dr Florey s Coat

Author: Eric Lax
Publisher: Henry Holt and Company
ISBN: 1627796444
Format: PDF, Mobi
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The untold story of the discovery of the first wonder drug, the men who led the way, and how it changed the modern world The discovery of penicillin in 1928 ushered in a new age in medicine. But it took a team of Oxford scientists headed by Howard Florey and Ernst Chain four more years to develop it as the first antibiotic, and the most important family of drugs in the twentieth century. At once the world was transformed-major bacterial scourges such as blood poisoning and pneumonia, scarlet fever and diphtheria, gonorrhea and syphilis were defeated as penicillin helped to foster not only a medical revolution but a sexual one as well. In his wonderfully engaging book, acclaimed author Eric Lax tells the real story behind the discovery and why it took so long to develop the drug. He reveals the reasons why credit for penicillin was misplaced, and why this astonishing achievement garnered a Nobel Prize but no financial rewards for Alexander Fleming, Florey, and his team. The Mold in Dr. Florey's Coat is the compelling story of the passage of medicine from one era to the next and of the eccentric individuals whose participation in this extraordinary accomplishment has, until now, remained largely unknown.

The Mold in Dr Florey s Coat

Author: Eric Lax
Publisher: Macmillan
ISBN: 9780805077780
Format: PDF, Docs
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The author of Life and Death on 10 West chronicles the fascinating true story of the Oxford scientists who discovered penicillin by experimenting on mold, creating a family of drugs that would eradicate some of the worst diseases in human history. Reprint. 35,000 first printing.

The Mold in Dr Florey s Coat

Author: Eric Lax
Publisher: Macmillan
ISBN: 9780805067903
Format: PDF, ePub, Mobi
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Chronicles the true story of the Oxford scientists who discovered penicillin by experimenting on mold, creating a family of drugs that would eradicate some of the worst diseases in human history.

Penicillin Man

Author: Kevin Brown
Publisher: The History Press
ISBN: 0750953470
Format: PDF, ePub, Docs
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Penicillin has affected the lives of everyone, and has exerted a powerful hold on the popular imagination since its first use in 1941. The story of its development from a chance observation in 1928 by Alexander Fleming to a life-saving drug is compelling and exciting. It revolutionized healthcare and turned the modest, self-effacing Fleming into a world hero. This book tells the story of the man and his discovery set against a background of the transformation of medical research from nineteenth-century individualism through to teamwork and modern-day international big business (pharmaceutical companies like Fisors, Distillers, or Beecham (Smith Kline)). Now, sixty years after the antibiotic revolution, when there are fears that the days of antibiotics are numbered it has never been more timely to look at the beginnings.

How to Win the Nobel Prize

Author: J. Michael BISHOP
Publisher: Harvard University Press
ISBN: 0674020979
Format: PDF
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In 1989 Michael Bishop and Harold Varmus were awarded the Nobel Prize for their discovery that normal genes under certain conditions can cause cancer. In this book, Bishop tells us how he and Varmus made their momentous discovery. More than a lively account of the making of a brilliant scientist, How to Win the Nobel Prize is also a broader narrative combining two major and intertwined strands of medical history: the long and ongoing struggles to control infectious diseases and to find and attack the causes of cancer. Alongside his own story, that of a youthful humanist evolving into an ambivalent medical student, an accidental microbiologist, and finally a world-class researcher, Bishop gives us a fast-paced and engrossing tale of the microbe hunters. It is a narrative enlivened by vivid anecdotes about our deadliest microbial enemies--the Black Death, cholera, syphilis, tuberculosis, malaria, smallpox, HIV--and by biographical sketches of the scientists who led the fight against these scourges. Bishop then provides an introduction for nonscientists to the molecular underpinnings of cancer and concludes with an analysis of many of today's most important science-related controversies--ranging from stem cell research to the attack on evolution to scientific misconduct. How to Win the Nobel Prize affords us the pleasure of hearing about science from a brilliant practitioner who is a humanist at heart. Bishop's perspective will be valued by anyone interested in biomedical research and in the past, present, and future of the battle against cancer. Table of Contents: List of Illustrations Preface 1. The Phone Call 2. Accidental Scientist 3. People and Pestilence 4. Opening the Black Box of Cancer 5. Paradoxical Strife Notes Credits Index Reviews of this book: Despite his book's encouraging title, Bishop--who won a Nobel Prize in Physiology and Medicine in 1989--cautions that "I have not written an instruction manual for pursuit of the prize." Instead, he has written an amiable reflection on the experience of being a Nobelist, intertwined with some history and anecdotes about the award, and balanced by a wide-ranging review of his own career as an "accidental scientist"...Along the way, Bishop reflects on the history of our knowledge of microbes, cancer, the politics of funding research and present-day disenchantment with science. His main purpose in writing this book, Bishop says, is to show that "scientists are supremely human"--which he does with grace and charm. --Publishers Weekly Reviews of this book: How to Win the Nobel Prize is typical Bishop: modest, funny, insightful and offering an extremely clear and brief explanation of the basic scientific achievement that won the 1989 Nobel Prize in physiology or medicine for himself and longtime colleague, Harold Varmus, now president of the Memorial Sloan-Kettering Cancer Center. --David Perlman, San Francisco Chronicle Reviews of this book: In these pages Bishop reveals himself as a good writer blessed with enviable clarity, someone sensible and levelheaded who likes people and is enamored of his science. --John Tyler Bonner, New York Times Book Review Reviews of this book: This is a treasure...Above all, How to Win the Nobel Prize is a civilised book and a lavishly rewarding one. --Roy Herbert, New Scientist Reviews of this book: At its heart this analysis of science and the scientific world is a jewel. How to Win the Nobel Prize is an inspirational book, full of careful analysis and judgement. --John Oxford, Times Higher Education Supplement Reviews of this book: Bishop is a gifted communicator and teacher, and he sets about his task of educating scientists and the public by describing his career in science and science politics...In the end, Bishop's book provides a road map for scientists and the public to build a robust scientific community that serves our society well. --Andreas Trumpp and Daniel Kalman, Nature Cell Biology J. Michael Bishop has written his book 'to show that scientists are supremely human.' The book is also a lucid explanation of how science has been harnessed to fight the human afflictions of cancer and infectious disease. And the story ends with a wide-ranging overview of today's challenges to the scientific enterprise. Overall, a must-read for all those interested in science and scientists--even those with absolutely no interest in winning a Nobel Prize! --Bruce Alberts, President, National Academy of Sciences J. Michael Bishop is that rare scientist who is widely read in literature and poetry. Most importantly, he remembers what he reads and thinks deeply about it, as well as about all else in his rich life. The Nobel Prize he won and richly deserved, his political activism, his understanding of cancer and microbiology, his devotion to the practice of science--all these provide fodder for his writerly craft. Quite a wonderful book! --David Baltimore, Nobel Laureate and President, California Institute of Technology

Ahead of the Curve

Author: Shane Crotty
Publisher: Univ of California Press
ISBN: 9780520225572
Format: PDF, ePub, Mobi
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A revealing portrait of one of the most important scientists of the last century reveals David Baltimore's groundbreaking work in molecular biology and, most recently, his search for an AIDS vaccine, as well as his involvement in the anti-war movement and his Nobel Prize.

The Mould in Dr Florey s Coat

Author: Eric Lax
Publisher: Abacus Software
ISBN: 9780349117683
Format: PDF, Mobi
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Many people know that in 1928 Alexander Fleming discovered penicillin's antibiotic potential while examining a stray mould that had bloomed in a dish of bacteria in his London laboratory. But few realise that Fleming worked only fitfully on penicillin until 1935, and that he is merely one character in the remarkable story of the antibiotic's development as a drug. The others are Howard Florey, Professor of Pathology at Oxford University, where he ran the Dunn School; the German Jewish emigre and biochemist Ernst Chain; and Norman Heatley, one of the few scientists in Britain capable of the micro-analysis of organic substances. It was these three men and their colleagues at the Dunn School who would battle a lack of money, a lack of resources and even each other to develop a drug that would change the world. It was these three men and their colleagues who would be almost forgotten. Why this happened, why it took fourteen years to develop penicillin, and how it was finally done, is a story of quirky individuals, missed opportunities, medical prejudice, brilliant science, shoestring research, wartime pressures and misplaced modesty.

Penicillin

Author: Robert Bud
Publisher: Oxford University Press on Demand
ISBN: 9780199254064
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Penicillin is the drug of the twentieth century. It was the first of the antibiotics that, for decades after the Second World War, underpinned a popular belief that the threat of infectious disease had at last met its match. With the emergence of 'superbugs' these hopes have faded. Robert Bud pulls these different but conjoined stories into a compelling narrative: using a wealth of new research, he sets the discovery and use of penicillin in the broader context of social and cultural change across the world. His book will be of great interest to historians, scientists, and anyone wishing to understand this drug's seismic impact on our lives.

Shock of Gray

Author: Ted Fishman
Publisher: Simon and Schuster
ISBN: 1416551034
Format: PDF, Docs
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In "Shock of Gray," Ted Fishman explains the astouding economic and political changes we face as our world suddenly grows old.