The Neutrophils

Author: Dmitry Gabrilovich
Publisher: World Scientific
ISBN: 1783262915
Format: PDF, ePub, Docs
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This is a third edition of the popular book, which presents an overview of the most recent findings in the biology of neutrophils. These cells are critically important for protection against bacterial and viral infections and have been recently demonstrated to be a major contributor to tumor associated immune suppression. In addition, neutrophils represent a unique model for studying fundamental questions of cellular biochemistry and molecular biology. This monograph provides a detailed description of signal transduction, generation of reactive oxygen, and mechanisms of migration and death of these cells. Besides that, it contains unique information regarding neutrophils' role in cancer. Finally, this monograph describes recent advances in attempts to improve neutrophil function and use these cells in the treatment of diseases. Contents:Molecular Regulation of Granulopoiesis (Sachin Kumar and Marie-Dominique Filippi)The Neutrophil Respiratory Burst Oxidase (Mark T Quinn)Novel Neutrophil Receptors and Their Signal Transduction (Nicole R Fortenbery, Xianhong Chen and Sheng Wei)Mechanisms of Neutrophil Migration (Fong W Lam, Rolando E Rumbaut and Alan R Burns)Cytokine Production by Neutrophils (Luc de Chaisemartin, Marco Cassatella and Sylvie Chollet-Martin)Neutrophils and Apoptosis (Christopher D Lucas and Adriano G Rossi)Regulation of Neutrophil Functions by Long Chain Fatty Acids (Antonio Ferrante, Charles S Hii and Bernadette Boog)S100 Calgranulins in Inflammation (Carolyn L Geczy, Phillipe A Tessier and Lincoln Gomes)Neutrophils and Myeloid-Derived Suppressor Cells in Cancer (Je-In Youn, Alex Corzo and Dmitry Gabrilovich)Colony-Stimulating Factors for Prevention and Treatment of Neutropenia and Infectious Diseases (David C Dale, Lee J Quinton and Steve Nelson) Readership: Students, professionals, cancer researchers, medical practitioners. Key Features:Comprehensive nature of the reviews of different aspects of neutrophil biologyFocus on cutting-edge discoveries in the fieldReview of neutrophils function in cancerKeywords:Neutrophils;Infection Diseases;Cancer;Cytokines;Apoptosis;Fatty Acids;Myeloid-Derived Suppressor Cells

The Neutrophils New Outlook for Old Cells

Author: Dmitry I Gabrilovich
Publisher: World Scientific
ISBN: 178326246X
Format: PDF, Docs
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This invaluable volume, written by group of internationally established scientists, presents an overview of the most recent findings on the biology of neutrophils. These cells have become a focus of attention in recent years because of their fascinating biochemistry and molecular biology and their ability to affect the functions of other cells. The book describes, in detail, the molecular events leading to neutrophil activation, migration, microbial killing, production of oxidative radicals and cytokines, and eventually to the death of these cells. It presents new information that has never been discussed in monographs before. It also gives a unique overview of the neutrophil's role in viral diseases, including Aids. Finally, the book describes how to improve the function of neutrophils and use these cells in the treatment of diseases. Contents:Molecular Basis of Neutrophil Activation (D English)The Respiratory Burst of Neutrophils: Oxidative Pathways for the Initiation of Tissue Damage at Sites of Inflammation (J W Heinecke)Mechanism of Leukocyte Accumulation in Postischemic Tissues: Role of Oxygen Free Radicals (J L Zweier)Regulation of Neutrophil Functions by Fatty Acids (A Ferrante et al.)Production of Cytokines by Polymorphonuclear Neutrophils (M A Cassatella)Neutrophils and Apoptosis (N F Fanning et al.)Neutrophil Migration and Methods for Its in vitro Study (A Rot)Diagnostic Evaluation of Neutrophil Function (G Virella)Neutrophils in Viral Infections (R L Roberts)Use of Colony-Stimulating Factors for Treatment of Neutropenia and Infectious Diseases (D C Dale & S Nelson)Neutrophil Transfusion Therapy (R G Strauss) Readership: Postgraduate students in immunology, biochemistry and cell/molecular biology. Keywords:Neutrophils;Cytokine;Respiratory Burst;Chemotaxis;Fatty Acid;Apoptosis;Infectious Diseases;Phagocytosis;Tyrosine Kinases;CSF

The Neutrophils

Author: Dmitry I. Gabrilovich
Publisher:
ISBN: 9781860944727
Format: PDF, Kindle
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- A unique review of neutrophil signaling, and the role of rac 1 and rac 2 in neutrophil function - The role of fatty acids in neutrophil function -- information not available in other books - The role of neutrophils in viral infections -- usually beyond the radar screen of investigators - The role of neutrophil function in cancer -- a topic of recent, great interest to many research groups

Medical Immunology Sixth Edition

Author: Gabriel Virella
Publisher: CRC Press
ISBN: 9781420020878
Format: PDF, Docs
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With an abundance of illustrations, diagrams, and algorithms, this sixth edition of Medical Immunology provides a reader-friendly review of critical material on the current diagnostic and clinical applications of immunology. Organized into four sections that describe clinical applications, methodological advances, immunological diseases, and innovative interventions, the book leads readers through state-of-the-sciences technologies and demonstrates their implementation in day-to-day clinical practice. Topics include: The genetics of immunoglobulins Diagnostic immunology Immune complex diseases Immune system modulators Lymphocyte and plasma cell malignancies The diagnosis of immunodeficiencies and secondary immunodeficiencies Applications of immunological assays to clinical diagnosis The diagnosis of disease in which the immune system plays a significant pathogenic role Edited by a distinguished educator with an extensive research background, the book also reviews the diagnosis, pathogenesis, and management of autoimmune diseases, hypersensitivity diseases, multiple myeloma, and other lymphoid diseases, and primary and secondary immune deficiency diseases.

Fibrocytes in Health and Disease

Author: Richard Bucala
Publisher: World Scientific
ISBN: 9814343722
Format: PDF, ePub, Mobi
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This volume provides a comprehensive and multidisciplinary overview of fibrocytes, written by the main researchers in the field. It is aimed at a broad audience of scientists and clinicians with an interest in the role of circulating fibrocytes in the etiopathogenesis of different fibrosing disorders, atherosclerosis, autoimmunity, and cancer.