Total Synthesis of Natural Products

Author: Jie Jack Li
Publisher: Springer Science & Business Media
ISBN: 3642340652
Format: PDF, Mobi
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'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.

Naturstoffe der chemischen Industrie

Author: Bernd Schäfer
Publisher: Spektrum Akademischer Verlag
ISBN: 9783827416148
Format: PDF, Docs
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Dieses Buch geht auf eine Vorlesung an der Universität Heidelberg zurück und richtet sich in erster Linie an Studenten, aber auch an Hochschuldozenten, Chemielehrer und Industriechemiker. Es vermittelt Einblicke in die moderne Naturstoffchemie und die Entwicklung komplexer Moleküle (asymmetrische und heterozyklische Verbindungen, polyzyklische Strukturen, makrozyklische und kleine Ringe) in der chemischen Industrie. Ein wichtiges Anliegen des Autors besteht darin, exemplarisch zu belegen, welche Aspekte eine Rolle spielen, wenn man im technischen Maßstab komplexe Verbindungen "auf elegantem Weg" herstellen will. So lernt der Leser die Grundlagen, die für einen jungen Chemiker in der chemischen Industrie unentbehrlich sind. Das Buch deckt ein breites Spektrum von Naturstoffen oder davon abgeleiteten Substanzen ab, darunter Farbstoffe wie etwa Indigo, in der Nahrungsmittelindustrie verwendete Verbindungen wie Coffein, Vanillin, Carotenoide und Aminosäuren, Arzneimittel wie Antibiotika, Opioide, Lipstatin und Steroide, Agrochemikalien wie Herbizide, Fungizide und Insektizide oder auch Duftstoffe wie Moschus und Damascon. Jedes Kapitel liefert auch historische und soziale Hintergrundinformationen zu dem jeweiligen Naturstoff und beschreibt seine biologische Aktivität, seine Entdeckung und seine wichtigsten Modifikationen durch die industrielle Chemie. In vielen Fällen wird die industrielle Synthese mit der Biosynthese verglichen. Überdies beleuchtet das Buch moderne Aspekte und zukünftige Entwicklungen in der Naturstoffsynthese. Ohne auf jeden industriell hergestellten Naturstoff einzugehen - was angesichts der Fülle der Substanzen in einem Lehrbuch auch gar nicht möglich ist -, bietet das verständlich geschriebene Werk einen guten Überblick über das gesamte Gebiet. Dabei kommt die "grüne Chemie" ebenso zur Sprache wie die Atomökonomie und "Eleganz" in der industriellen Naturstoffsynthese.

Efficiency in Natural Product Total Synthesis

Author: Pei-Qiang Huang
Publisher: John Wiley & Sons
ISBN: 1118940210
Format: PDF, Docs
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Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. • Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science • Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis • Appeals to graduate students with two sections at the end of each chapter illustrating key reactions, strategies, tactics, and concepts; and good but unfinished total synthesis (synthesis of core structure) before the last section • Compiles examples of solid phase synthesis and continuing flow chemistry-based total synthesis which are very relevant and attractive to industry R&D professionals

Frontiers in Natural Product Chemistry

Author: Atta-ur-Rahman
Publisher: Bentham Science Publishers
ISBN: 1608052125
Format: PDF, Mobi
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“Frontiers in Natural Product Chemistry” is an Ebook series devoted to publishing the latest and most important advances in natural product chemistry. The Ebook series covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds including coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussion of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of new methods are included. Chosen eminent scientists write contributions and each volume are devoted to major advances in natural product chemistry. Topics include the isolation, structure, biosynthesis, biological activity, and chemistry of the major groups of natural products such as alkaloids, terpenoids, steroids, aliphatic, aromatic and O-heterocyclic compounds, and other metabolites of plant, marine and microbial origins, developments in enzymology, nucleic acids, genetics, chemical ecology, primary and secondary metabolism, isolation and analytical techniques, and other areas which will be of general interest to all workers in the area. “Frontiers in Natural Product Chemistry” is essential for all scientists involved in natural product chemistry who wish to keep abreast of rapid and important developments in the field.

Name Reactions

Author: Jie Jack Li
Publisher: Springer Science & Business Media
ISBN: 3319039792
Format: PDF, Kindle
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In this fifth edition of Jack Jie Li's seminal "Name Reactions", the author has added twenty-seven new name reactions to reflect the recent advances in organic chemistry. As in previous editions, each reaction is delineated by its detailed step-by-step, electron-pushing mechanism and supplemented with the original and the latest references, especially from review articles. Now with addition of many synthetic applications, this book is not only an indispensable resource for advanced undergraduate and graduate students, but is also a good reference book for all organic chemists in both industry and academia. Unlike other books on name reactions in organic chemistry, Name Reactions, A Collection of Detailed Reaction Mechanisms and Synthetic Applications focuses on the reaction mechanisms. It covers over 320 classical as well as contemporary name reactions.

Frontiers of Bioorganic Chemistry and Molecular Biology

Author: S. N. Ananchenko
Publisher: Elsevier
ISBN: 1483278832
Format: PDF, ePub, Docs
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Frontiers of Bioorganic Chemistry and Molecular Biology covers the proceedings of the International Symposium on Frontiers of Bioorganic Chemistry and Molecular Biology, held in Moscow and Tashkent, USSR on September 25-October 2, 1978. This symposium is devoted to a discussion of the physico-chemical basis of life processes. This book contains 56 chapters, and reflects the results in the study of peptides and proteins, nucleic acids, polysaccharides, and other biopolymers. Other chapters deal with the study of low molecular regulators, including steroids, alkaloids, and antibiotics. This book also includes discussion of the achievements in the study of genetic structures and of cellular protein synthesizing systems of the molecular basis of enzymic catalysis and of bioenergetic processes. This book will be of value to biochemists and molecular biologists.

Bioactive Natural Products

Author: Goutam Brahmachari
Publisher: John Wiley & Sons
ISBN: 3527684425
Format: PDF, ePub, Docs
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Natural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to kill a cancer cell. This book comprising of sixteen technical chapters, highlights the chemical and biological aspects of potential natural products with an intention of unravelling their pharmaceutical applicability in modern drug discovery processes. Key features: Covers the synthesis, semi-synthesis and also biosynthesis of potentially bioactive natural products Features chemical and biological advances in naturally occurring organic compounds describing their chemical transformations, mode of actions, and structure-activity relationships 40 expert scientists from around the world report their latest findings and outline future opportunities for the development of novel and highly potent drugs based on natural products operating at the interface of chemistry and biology Forward-looking: Addresses opportunities and cutting-edge developments rather than well-documented basic knowledge, pinpoints current trends and future directions in this rapidly-evolving field Application-oriented: Throughout the book, the focus is on actual and potential applications in pharmacology and biotechnology This book is an essential resource for natural products chemists, medicinal chemists, biotechnologists, biochemists, pharmacologists, as well as the pharmaceutical and biotechnological industries.

The Way of Synthesis

Author: Tomas Hudlicky
Publisher: Wiley-VCH
ISBN:
Format: PDF, Mobi
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This two-colored textbook presents not only synthetic ways to design organic compounds, it also contains a compilation of the most important total synthesis of the last 50 years with a comparative view of multiple designs for the same targets. It explains different tactics and strategies, making it easy to apply to many problems, regardless of the synthetic question in hand. Following a historical view of the evolution of synthesis, the book goes on to look at principles and issues impacting synthesis and design as well as principles and issues of methods. The sections on comparative design cover classics in terpenes and alkaloid synthesis, while a further section covers such miscellaneous syntheses as Maytansine, Palytoxin, Brevetoxin B and Indinavir. The whole is rounded off with a look at future perspectives and, what makes this textbook extraordinairy, with personal recollections of the chemists, who synthesized these fascinating compounds. With its attractive layout highlighting key parts and tactics using a second color, this is a useful tool for organic chemists, lecturers and students in chemistry, as well as those working in the chemical industry. "I think, as will many organic chemists, that the Hudlicky book will be the Bible of synthetic organic chemistry, the past, the present and the future. A hallmark publication." (Victor Snieckus)