Translational Endocrinology of Bone

Author: Gerard Karsenty
Publisher: Academic Press
ISBN: 012415784X
Format: PDF, ePub, Mobi
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The use of model organisms together with the power of genetics has profoundly affected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. First, the use of mouse genetics, guided by clinical observations has revealed, besides the classical regulation by the parathyroid hormone and sex steroid hormones, totally unanticipated ways of regulating bone mass. These include the influence of adipocytes, pancreatic b-cells, and entero-chromaffin cells of the duodenum on the central and peripheral nervous systems. A second major advance of the last decade has been to show that bone has many more functions than the one classically ascribed to it and described in other textbooks. These include but are not limited to the regulation of glucose metabolism, fertility, and phosphate homeostasis. This will be the first translational reference to focus on these major conceptual advances in bone biology and their development in the clinic. Several advances have already been translated into therapies and others are being tested for diseases as different as osteoporosis, type-2 diabetes, and hypo-fertility. Summarizes the latest research and translational applications of how the varied growth and development of bone affects appetite, metabolism, reproduction, and a wide range of endocrine functions Provides a common language for bone biologists, endocrinologists, osteologists, and other researchers, such as neuroscientists, who study appetite, fuel metabolism and diabetes, to discuss the development of translational research and new therapeutic strategies for bone, metabolic, and neuro-endocrine diseases. Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone research and therapeutics, as opposed to searching through thousands of journal articles

Cellular Endocrinology in Health and Disease

Author: Alfredo Ulloa-Aguirre
Publisher: Elsevier
ISBN: 0124167128
Format: PDF, ePub, Docs
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Cellular Endocrinology in Health and Disease describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. Among these are those whose function was not obvious until recently, including the endocrine functions of bone and the adipose tissue. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and P. Michael Conn, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts. Covers systemic endocrine action at the cellular level in both health and disease Delivers information on the integration of cell identity and endocrinology Incorporates recent developments in endocrinology to provide an up-to-date reference to researchers

Textbook of Nephro Endocrinology

Author: Ajay K. Singh
Publisher: Academic Press
ISBN: 0128032480
Format: PDF, Docs
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Textbook of Nephro-Endocrinology, Second Edition, continues to be the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and hypoparathyroidism. Changes to this edition include new chapters focused on hypercalcemia/hypocalcemia and the interaction of dialysis, chronic renal disease, and endocrine diseases. All chapters have been updated to include more preclinical data and more tables and schema that help translate this data into clinical recommendations. The section on hormones and renal insufficiency discusses insulin/diabetes, growth hormone, sex steroids, thyroid hormone, acid–base disturbances, and pregnancy. Presents a uniquely comprehensive and cross-disciplinary look at all aspects of nephro-endocrine disorders in one reference Investigates both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems Offers clear translational presentations by the top endocrinologists and nephrologists in each specific hormone or functional/systems field Features new and updated chapters that include more tables and schema to help translate preclinical data into clinical recommendations

Principles of Bone Biology

Author: John P. Bilezikian
Publisher: Academic Press
ISBN: 9780080568751
Format: PDF, Docs
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Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition

Endocrinology

Author: Shlomo Melmed
Publisher: Springer Science & Business Media
ISBN: 1592598293
Format: PDF, Docs
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Maintaining the original goal of the first edition to integrate the basic science of endocrinology with its physiological and clinical principles, this new edition succinctly summarizes in 450 pages the latest findings on hormone secretion and hormone action, as well as all the most recent insights into the physiology and pathophysiology of hormonal disorders. Coverage extends across the entire spectrum of endocrinology-from mammalian cells, plants, and insects to animal models and human diseases-with much increased coverage of diabetes and metabolism. Highlights include cutting-edge discussions of appetite disorders, obesity, reproductive failure, control of thyroid function, hormone action in man and the lower species, and the mechanisms subserving hormone secretion.

Animal Models for the Study of Human Disease

Author: P. Michael Conn
Publisher: Academic Press
ISBN: 0128096993
Format: PDF, ePub
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Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives, and animal ethics Covers a broad range of animal models used in research for human disease Contributed by leading experts across the globe Expanded coverage of diabetes and neurological diseases

Research Centers Directory

Author:
Publisher:
ISBN:
Format: PDF, Mobi
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Research institutes, foundations, centers, bureaus, laboratories, experiment stations, and other similar nonprofit facilities, organizations, and activities in the United States and Canada. Entry gives identifying and descriptive information of staff and work. Institutional, research centers, and subject indexes. 5th ed., 5491 entries; 6th ed., 6268 entries.

Vitamin D

Author: David Feldman
Publisher: Elsevier
ISBN: 9780080543642
Format: PDF, ePub, Docs
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Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This second edition includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must have resource for anyone working in endocrinology, osteology, bone biology, or cancer research. *Most comprehensive, up-to-date two-volume set on Vitamin D *New chapters on squamous cell cancer, brain cancer, thyroid cancer and many more *Further sections on emerging uses for treatments of auto-immune diseases and diabetes *Over 600 illustrations and figures available on CD