Transmembrane Dynamics of Lipids

Author: Philippe Devaux
Publisher: John Wiley & Sons
ISBN: 0470388455
Format: PDF, Kindle
Download Now
"The multi-authored book contains modern information on all major aspects related to the formation, stability and biological consequences of the asymmetrical organization of lipids in cell membranes. It introduces the phenomenon of membrane asymmetry, describes transmembrane distribution of lipids in biological membranes, represents methods for the measurement of the transmembrane lipid motion, emphasizes the role of flippases, discusses biological functions associated with lipid asymmetry and outlines correlations between lipid asymmetry and human diseases such as thrombosis, cancer, and apoptosis"--

Biophysics

Author: Roland Glaser
Publisher: Springer Science & Business Media
ISBN: 3642252125
Format: PDF, ePub, Docs
Download Now
Biophysics is the science of physical principles underlying all processes of life, including the dynamics and kinetics of biological systems. This fully revised 2nd English edition is an introductory text that spans all steps of biological organization, from the molecular, to the organism level, as well as influences of environmental factors. In response to the enormous progress recently made, especially in theoretical and molecular biophysics, the author has updated the text, integrating new results and developments concerning protein folding and dynamics, molecular aspects of membrane assembly and transport, noise-enhanced processes, and photo-biophysics. The advances made in theoretical biology in the last decade call for a fully new conception of the corresponding sections. Thus, the book provides the background needed for fundamental training in biophysics and, in addition, offers a great deal of advanced biophysical knowledge.

Lipidomics

Author: Kim Ekroos
Publisher: John Wiley & Sons
ISBN: 3527655964
Format: PDF, ePub, Mobi
Download Now
Focusing on the practical applications, this user-oriented guide presents current technologies and strategies for systems-level lipid analysis, going beyond basic research to concentrate on commercial uses of lipidomics in biomarker and diagnostic development, as well as within pharmaceutical drug discovery and development. The editor and authors have experience of the most recent analytical instruments and techniques, allowing them to provide here first-hand practical experience for newcomers to the field. The first half of the book covers current methodologies, ranging from global to targeted lipidomics and shotgun approaches, while the second part discusses the role of lipidomics in biomedical and pharmaceutical research, covering such diverse fields as inflammation, metabolic syndrome, cardiovascular and neurological disease. Both small and large-scale, high-throughput approaches are discussed, resulting in an invaluable source for academic and industrial research and development.

Protein and Peptide Folding Misfolding and Non Folding

Author: Reinhard Schweitzer-Stenner
Publisher: John Wiley & Sons
ISBN: 1118183355
Format: PDF, ePub
Download Now
Sheds new light on intrinsically disordered proteins andpeptides, including their role in neurodegenerative diseases With the discovery of intrinsically disordered proteins andpeptides (IDPs), researchers realized that proteins do notnecessarily adopt a well defined secondary and tertiary structurein order to perform biological functions. In fact, IDPs playbiologically relevant roles, acting as inhibitors, scavengers, andeven facilitating DNA/RNA-protein interactions. Due to theirpropensity for self-aggregation and fibril formation, some IDPs areinvolved in neurodegenerative diseases such as Parkinson's andAlzheimer's. With contributions from leading researchers, this text reviewsthe most recent studies, encapsulating our understanding of IDPs.The authors explain how the growing body of IDP research isbuilding our knowledge of the folding process, the binding ofligands to receptor molecules, and peptide self-aggregation.Readers will discover a variety of experimental, theoretical, andcomputational approaches used to better understand the propertiesand function of IDPs. Moreover, they'll discover the role of IDPsin human disease and as drug targets. Protein and Peptide Folding, Misfolding, and Non-Folding beginswith an introduction that explains why research on IDPs hassignificantly expanded in the past few years. Next, the book isdivided into three sections: Conformational Analysis of Unfolded States Disordered Peptides and Molecular Recognition Aggregation of Disordered Peptides Throughout the book, detailed figures help readers understandthe structure, properties, and function of IDPs. References at theend of each chapter serve as a gateway to the growing body ofliterature in the field. With the publication of Protein and Peptide Folding, Misfolding,and Non-Folding, researchers now have a single place to discoverIDPs, their diverse biological functions, and the many disciplinesthat have contributed to our evolving understanding of them.

Protein Oxidation and Aging

Author: Tilman Grune
Publisher: John Wiley & Sons
ISBN: 111849301X
Format: PDF, Kindle
Download Now
Reviews our current understanding of the role of proteinoxidation in aging and age-related diseases Protein oxidation is at the core of the aging process. Settingforth a variety of new methods and approaches, this book helpsresearchers conveniently by exploring the aging process anddeveloping more effective therapies to prevent or treat age-relateddiseases. There have been many studies dedicated to therelationship between protein oxidation and age-related pathology;now it is possible for researchers and readers to learn newtechniques as utilizing protein oxidation products as biomarkersfor aging. Protein Oxidation and Aging begins with a description ofthe tremendous variety of protein oxidation products. Furthermore,it covers: Major aspects of the protein oxidation process Cellular mechanisms for managing oxidized proteins Role of protein oxidation in aging Influence of genetic and environmental factors on proteinoxidation Measuring protein oxidation in the aging process Protein oxidation in age-related diseases References at the end of each chapter serve as a gateway to thegrowing body of original research studies and reviews in thefield.

Transmembrane Dynamics of Lipids

Author: Philippe Devaux
Publisher: John Wiley & Sons
ISBN: 0470388455
Format: PDF, ePub, Mobi
Download Now
"The multi-authored book contains modern information on all major aspects related to the formation, stability and biological consequences of the asymmetrical organization of lipids in cell membranes. It introduces the phenomenon of membrane asymmetry, describes transmembrane distribution of lipids in biological membranes, represents methods for the measurement of the transmembrane lipid motion, emphasizes the role of flippases, discusses biological functions associated with lipid asymmetry and outlines correlations between lipid asymmetry and human diseases such as thrombosis, cancer, and apoptosis"--

Viral Membrane Proteins Structure Function and Drug Design

Author: Wolfgang B. Fischer
Publisher: Springer Science & Business Media
ISBN: 9780387281469
Format: PDF, ePub
Download Now
In Viral Membrane Proteins: Structure, Function, and Drug Design, Wolfgang Fischer summarizes the current structural and functional knowledge of membrane proteins encoded by viruses. In addition, contributors to the book address questions about proteins as potential drug targets. The range of information covered includes signal proteins, ion channels, and fusion proteins. This book has a place in the libraries of researchers and scientists in a wide array of fields, including protein chemistry, molecular biophysics, pharmaceutical science and research, bioanotechnology, molecular biology, and biochemistry.

Protein Lipid Interactions

Author: Lukas K. Tamm
Publisher: John Wiley & Sons
ISBN: 3527606998
Format: PDF, ePub, Mobi
Download Now
In 17 contributions by leading research groups, this first comprehensive handbook in the field covers the interactions between proteins and lipids that make the fabric of biological membranes from every angle. It examines the relevant hermodynamic and structural issues from a basic science perspective, and goes on to discuss biochemical and cell biological processes. The book covers physical principles as well as mechanisms of membrane fusion and fission. Additionally, chapters on bilayer structure and protein-lipid interactions as well as on how proteins shape lipids and vice versa, membrane penetration by toxins, protein sorting, and allosteric regulation of signal transduction across membranes make this a valuable information source for researchers in academia and industry.

Biophysical Analysis of Membrane Proteins

Author: Eva Pebay-Peyroula
Publisher: John Wiley & Sons
ISBN: 3527621237
Format: PDF, Docs
Download Now
Meeting the need for a book on developing and using new methods to investigate membrane proteins, this is the first of its kind to present the full range of novel techniques in one resource. Top researchers from around the world focus on the physical principles exploited in the different techniques, and provide examples of how these can bring about important new insights. Following an introduction, further sections discuss structural approaches, molecular interaction and large assemblies, dynamics and spectroscopies, finishing off with an exploration of structure-function relationships in whole cells.

Proteins in Solution and at Interfaces

Author: Juan M. Ruso
Publisher: John Wiley & Sons
ISBN: 1118523172
Format: PDF, ePub, Docs
Download Now
Explores new applications emerging from our latestunderstanding of proteins in solution and at interfaces Proteins in solution and at interfaces increasingly serve as thestarting point for exciting new applications, from biomimeticmaterials to nanoparticle patterning. This book surveys the stateof the science in the field, offering investigators a currentunderstanding of the characteristics of proteins in solution and atinterfaces as well as the techniques used to study thesecharacteristics. Moreover, the authors explore many of the new andemerging applications that have resulted from the most recentstudies. Topics include protein and protein aggregate structure;computational and experimental techniques to study proteinstructure, aggregation, and adsorption; proteins in non-standardconditions; and applications in biotechnology. Proteins in Solution and at Interfaces is divided intotwo parts: Part One introduces concepts as well as theoretical andexperimental techniques that are used to study protein systems,including X-ray crystallography, nuclear magnetic resonance, smallangle scattering, and spectroscopic methods Part Two examines current and emerging applications,including nanomaterials, natural fibrous proteins, and biomolecularthermodynamics The book's twenty-three chapters have been contributed byleading experts in the field. These contributions are based on athorough review of the latest peer-reviewed findings as well as theauthors' own research experience. Chapters begin with a discussionof core concepts and then gradually build in complexity, concludingwith a forecast of future developments. Readers will not only gain a current understanding of proteinsin solution and at interfaces, but also will discover howtheoretical and technical developments in the field can betranslated into new applications in material design, geneticengineering, personalized medicine, drug delivery, biosensors, andbiotechnology.