R for Medicine and Biology

Author: Paul D. Lewis
Publisher: Jones & Bartlett Publishers
ISBN: 1449613101
Format: PDF, Docs
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R is quickly becoming the number one choice for users in the fields of biology, medicine, and bioinformatics as their main means of storing, processing, sharing, and analyzing biomedical data. R for Medicine and Biology is a step-by-step guide through the use of the statistical environment R, as used in a biomedical domain. Ideal for healthcare professionals, scientists, informaticists, and statistical experts, this resource will provide even the novice programmer with the tools necessary to process and analyze their data using the R environment. Introductory chapters guide readers in how to obtain, install, and become familiar with R and provide a clear introduction to the programming language using numerous worked examples. Later chapters outline how R can be used, not just for biomedical data analysis, but also as an environment for the processing, storing, reporting, and sharing of data and results. The remainder of the book explores areas of R application to common domains of biomedical informatics, including imaging, statistical analysis, data mining/modeling, pathology informatics, epidemiology, clinical trials, and metadata usage. R for Medicine and Biology will provide you with a single desk reference for the R environment and its many capabilities.

5th International Conference on Practical Applications of Computational Biology Bioinformatics

Author: Miguel P. Rocha
Publisher: Springer Science & Business Media
ISBN: 9783642199141
Format: PDF, Docs
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The growth in the Bioinformatics and Computational Biology fields over the last few years has been remarkable and the trend is to increase its pace. In fact, the need for computational techniques that can efficiently handle the huge amounts of data produced by the new experimental techniques in Biology is still increasing driven by new advances in Next Generation Sequencing, several types of the so called omics data and image acquisition, just to name a few. The analysis of the datasets that produces and its integration call for new algorithms and approaches from fields such as Databases, Statistics, Data Mining, Machine Learning, Optimization, Computer Science and Artificial Intelligence. Within this scenario of increasing data availability, Systems Biology has also been emerging as an alternative to the reductionist view that dominated biological research in the last decades. Indeed, Biology is more and more a science of information requiring tools from the computational sciences. In the last few years, we have seen the surge of a new generation of interdisciplinary scientists that have a strong background in the biological and computational sciences. In this context, the interaction of researchers from different scientific fields is, more than ever, of foremost importance boosting the research efforts in the field and contributing to the education of a new generation of Bioinformatics scientists. PACBB‘11 hopes to contribute to this effort promoting this fruitful interaction. PACBB'11 technical program included 50 papers from a submission pool of 78 papers spanning many different sub-fields in Bioinformatics and Computational Biology. Therefore, the conference will certainly have promoted the interaction of scientists from diverse research groups and with a distinct background (computer scientists, mathematicians, biologists). The scientific content will certainly be challenging and will promote the improvement of the work that is being developed by each of the participants.

Statistics at the Bench

Author: Martina Bremer
Publisher:
ISBN:
Format: PDF, Kindle
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Statistics at the Bench is a convenient bench-side companion for biologists, designed as a handy reference guide for elementary and intermediate statistical analyses. The expectations for biologists to have a more complete understanding of statistics are growing rapidly. New technologies and new areas of science, such as microarrays, next-generation sequencing, and proteomics, have dramatically increased the need for quantitative reasoning among biologists when designing experiments and interpreting results. Even the most routine informatics tools rely on statistical assumptions and methods that need to be appreciated if the scientific results are to be correct, understood, and exploited fully. This book is not a textbook. It is an essential handbook for working scientists. Statistics at the Bench provides a simple refresher for those who have forgotten what they once knew, and an overview for those wishing to use more quantitative reasoning in their research. Statistical methods, as well as guidelines for the interpretation of results, are explained using simple examples. Throughout the book, examples are accompanied by detailed Excel commands for easy reference.

End User Development

Author: Henry Lieberman
Publisher: Springer Science & Business Media
ISBN: 140205386X
Format: PDF, Kindle
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This book makes important aspects of the international discussion on End User Development (EUD) available to a broader audience. It offers a unique set of contributions from research institutes worldwide, addressing relevant issues and proposing original solutions. This broad look at the emerging paradigm of End-User Development will inspire every reader to appreciate its potential for the future. Indeed, the editors hope that readers – "end-users" - will themselves become developers.

Encyclopedia of Cell Biology

Author:
Publisher: Academic Press
ISBN: 0123947960
Format: PDF
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The Encyclopedia of Cell Biology offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced researcher. With authored contributions by experts in the field, the Encyclopedia of Cell Biology provides a fully cross-referenced, one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences. Fully annotated color images and videos for full comprehension of concepts, with layered content for readers from different levels of experience Includes information on cytokinesis, cell biology, cell mechanics, cytoskeleton dynamics, stem cells, prokaryotic cell biology, RNA biology, aging, cell growth, cell Injury, and more In-depth linking to Academic Press/Elsevier content and additional links to outside websites and resources for further reading A one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences

Annual Plant Reviews Biology of Plant Metabolomics

Author: Robert D. Hall
Publisher: John Wiley & Sons
ISBN: 144433994X
Format: PDF, ePub, Mobi
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Following a general introduction to the book, the first section of the book will include details of metabolomics of model species, including Arabidopsis, tomato and the legume Medicago. Chapters within the second section will consider the use and inter relationships of data integration, systems biology, genetics, genomics, metabolomics, chemometrics and biostatisitcs. The final section of the book will look at the use of metabolomics in food science, plant ecology, biodiversity and bioprocessing.Plant Metabolomicsis an essential purchase for plant scientists, plant geneticists and physiologists.

DNA Microarrays Part A Array Platforms and Wet Bench Protocols

Author:
Publisher: Elsevier
ISBN: 9780080464657
Format: PDF, ePub
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Modern DNA microarray technologies have evolved over the past 25 years to the point where it is now possible to take many million measurements from a single experiment. These two volumes, Parts A & B in the Methods in Enzymology series provide methods that will shepard any molecular biologist through the process of planning, performing, and publishing microarray results. Part A starts with an overview of a number of microarray platforms, both commercial and academically produced and includes wet bench protocols for performing traditional expression analysis and derivative techniques such as detection of transcription factor occupancy and chromatin status. Wet-bench protocols and troubleshooting techniques continue into Part B. These techniques are well rooted in traditional molecular biology and while they require traditional care, a researcher that can reproducibly generate beautiful Northern or Southern blots should have no difficulty generating beautiful array hybridizations. Data management is a more recent problem for most biologists. The bulk of Part B provides a range of techniques for data handling. This includes critical issues, from normalization within and between arrays, to uploading your results to the public repositories for array data, and how to integrate data from multiple sources. There are chapters in Part B for both the debutant and the expert bioinformatician. Provides an overview of platforms Includes experimental design and wet bench protocols Presents statistical and data analysis methods, array databases, data visualization and meta-analysis

Laboratory Investigations in Molecular Biology

Author: Steven A. Williams
Publisher: Jones & Bartlett Learning
ISBN: 9780763733292
Format: PDF
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This book presents well-tested protocols in molecular biology that are commonly used in currently active research labs. It is an ideal laboratory manual for college level courses in molecular biology. Because of the modular organization of the manual, laboratory courses can be assembled that would be ideal for science professionals, graduate students, undergraduate students and even advanced high school students in AP courses.

Research Techniques in Biochemistry and Molecular Biology

Author: Robert E. Thach
Publisher:
ISBN:
Format: PDF, ePub
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PREPARATION OF THE CRUDE CELL LYSATE; PURIFICATION OF POLYCUCLEOTIDE PHOSPHORYLASE BY AMMONIUM SUL FATE FRACTIONATION; MEASUREMENT OF POLYNUCLEOTIDE PHOSPHORYLASE ACTIVITY; DETERMINATION OF PROTEIN AND NUCLEIC ACID CONCENTRATIONS; TEMOVAL OF NUCLEASE CONTAMINANTS BY POLYNUCLEOTIDES; ANALYSIS OF POLYNUCLEOTIDE PRODUCTS; MOLECULAR WEIGHT DETERMINATION OF POLYMERS BY VISCOMETRY; PROTEIN SYNTHESIS IN VITRO: CRACKING THE GENETIC CODE; MEDRANISM OF PROTEIN SYNTHESIS: INCOLVEMENT OF RIBOSOMES; ISOLATION AND IDENTIFICATION OF TRANSFER RNA; SEPARATION OF ACTIVATING ENZYMES; PROOF THAT AMINOACYL-TRNA IS AN OBLIGATORY INTERMEDIATE IN POLYPEPTIDE SYNTHESIS.

Drosophila Protocols

Author: William Sullivan
Publisher: CSHL Press
ISBN: 9780879695866
Format: PDF, Mobi
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This exceptional laboratory manual describes thirty-seven procedures most likely to be used in the next decade for molecular, biochemical, and cellular studies on Drosophila. They were selected after extensive consultation with the research community and rigorously edited for clarity, uniformity, and conciseness.The methods included permit investigation of chromosomes, cell biology, molecular biology, genomes, biochemistry, and development. Each protocol includes the basic information needed by novices, with sufficient detail to be valuable to experienced investigators. Each method is carefully introduced and illustrated with figures, tables, illustrations, and examples of the data obtainable. The book's appendices include key aspects of Drosophila biology, essential solutions, buffers, and recipes.An evolution of Michael Ashburner's 1989 classic Drosophila: A Laboratory Manual, this book is an essential addition to the personal library of Drosophila investigators and an incomparable resource for other research groups with goals likely to require fly-based technical approaches.