Voltage Gated Sodium Channels

Author: Peter C. Ruben
Publisher: Springer Science & Business Media
ISBN: 3642415881
Format: PDF, ePub
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A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Voltage Gated Sodium Channels

Author: Peter Ruben
Publisher: Springer
ISBN: 9783642415876
Format: PDF, ePub
Download Now
A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Voltage gated Sodium Channels Structure Function and Channelopathies

Author: Mohamed Chahine
Publisher: Springer
ISBN: 3319902849
Format: PDF
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This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.

Na Channels from Phyla to Function

Author:
Publisher: Academic Press
ISBN: 012809253X
Format: PDF, Kindle
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Na Channels from Phyla to Function, the latest volume in the Current Topics in Membranes series, is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up-to-date presentation of the current knowledge in the field of Na Channels. Written by leading experts in the field of Na Channels Contains original material, both textual and illustrative, that make it a very relevant reference Presented in a very comprehensive manner Both researchers in the field and general readers will find this book relevant and up-to-date with regard to its information

Chemical and Biochemical Approaches for the Study of Anesthetic Function

Author:
Publisher: Academic Press
ISBN: 0128127414
Format: PDF, Kindle
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Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part A, Volume 602 assembles new information on our understanding of anesthesia. This latest release in the series includes sections on how physical accuracy leads to biological relevance, best practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion channels modulation by general anesthetics, anesthetic parameterization, pharmacophore QSAR, QM, ONIOM, and kinetic modeling of electrophysiology data. We have selected the primary experts to write about each approach This provides one-stop shopping for all the means of addressing this complex question Anesthesia is enormously important as almost everybody receives it at some point

Allgemeine und spezielle Pharmakologie und Toxikologie

Author: Klaus Aktories
Publisher: Elsevier Health Sciences
ISBN: 3437172123
Format: PDF, ePub, Docs
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Wer mit „Aktories" lernt, versteht Das gesamte Wissen der Pharmakologie und Toxikologie ist so verständlich und anschaulich erklärt, dass man seit Jahrzehnten auf dieses Standardwerk schwört. Mit über 1200 Seiten, rund 800 Abbildungen und 300 Tabellen ist diese 12. Auflage auf dem neuesten Stand der Wissenschaft: Arzneimittelwirkungen im Gesamtzusammenhang begreifen: Wirkmechanismen und pathophysiologische Bezüge in jedem Kapitel Zusammenhänge verstehen: Ausführliches Kapitel zur allgemeinen Pharmakologie und Toxikologie erleichtert das Verständnis der speziellen pharmakologischen Zusammenhänge Praktische Relevanz: Empfehlungen zu Therapie und Dosierungen in farbig hervorgehobenen Kästen Der „Aktories" – bewährt als erstklassiges Lehrbuch für Medizinstudenten, begehrt als Nachschlagewerk für Ärzte, Pharmakologen und Pharmazeuten.

Pharmacology and Therapeutics for Dentistry E Book

Author: John A. Yagiela
Publisher: Elsevier Health Sciences
ISBN: 0323078249
Format: PDF
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Use your knowledge of pharmacology to enhance oral care! Pharmacology and Therapeutics for Dentistry, 6th Edition describes how to evaluate a patient’s health and optimize dental treatment by factoring in the drugs they take. It explores the basic fundamentals of pharmacology, special topics such as pain control, fear and anxiety, and oral complications of cancer therapy, and most importantly, the actions of specific drug groups on the human body. Whether you’re concerned about the drugs a patient is already taking or the drugs you prescribe for treatment, this book helps you reduce risk and provide effective dental care. An emphasis on the dental applications of pharmacology relates drugs to dental considerations in clinical practice. Dental aspects of many drug classes are expanded to include antibiotics, analgesics, and anesthetics. The Alternative Medicine in Dentistry chapter discusses chemicals used as alternative medicines and assesses their potential benefits and risks. The Nonopioid Analgesics chapter groups together non-opioid analgesics, nonsterioidal anti-inflammatory drugs, and antirheumatic and antigout drugs, making these easier to locate and study. Coverage of the endocrine system includes four separate chapters for the most comprehensive coverage. Drug Interactions in Clinical Dentistry appendix lists potential interactions between drugs a patient is taking for nondental conditions and drugs that may be used or prescribed during dental treatment, including effects and recommendations. Glossary of Abbreviations appendix includes the most common abbreviations used for drugs or conditions. New Pharmacogenetics and Pharmacogenomics chapter covers the effects of genetic traits of patients on their responses to drugs. A NEW introductory section offers tips for the study of dental pharmacology and relates pharmacology to dental considerations. An updated discussion of drug-drug interactions covers the harmful effects of mixing medications. Coverage of adverse effects and mechanisms of COX-2 inhibitors, antibiotic prophylaxis, and antiplaque agents explains the dental risks relating to common drug treatments.

Goodman Gilman s the Pharmacological Basis of Therapeutics

Author: Louis Sanford Goodman
Publisher: McGraw-Hill Companies
ISBN:
Format: PDF
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For more than fifty years, scientists, clinicians, & students have relied on "Goodman & Gilman for the final word on the pharmacokinetics, mechanisms of action & therapeutic application of drugs. This edition sustains that proud tradition & infuses the latest information on molecular pharmacology as it redefines the definite database of pharmacologic therapeutics. As a course text or a daily reference in clinical practice, "G & G" offers the optimal mix of basic science & clinical coverage as it pertains to effective drug therapy.

Goodman and Gilman s the Pharmacological Basis of Therapeutics

Author: Louis Sanford Goodman
Publisher: McGraw-Hill
ISBN: 9780071354691
Format: PDF
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Goodman & Gilman is the Bible of pharmacology as it has been since the first edition written by Louis Goodman and Alfred Gilman and published in 1941. It is the definitive textbook for all medical and pharmacy students and is a must have purchase for residents in internal medicine and pharmacologists. The book is a higher level than our Katzung and should be considered as the perfect accompaniment to the new Harrison. The objective of this textbook/ reference work is to provide a comprehensive and up-to-date correlation of pharmacology with related medical sciences, a reinterpretation of the actions and uses of drug from the view point of the latest advances in medicine and pace emphasis on the application of pharmacodynamics to therapeutics. Throughout its history, Goodman & Gilman has become more than a textbook. It is a working template for effective and rational prescribing of drugs in daily practice. The careful balance of basic science and clinical application has guided students and practitioners to a better understanding of how and why drugs work. The information is presented in a style that reads with maximum clarity and purpose. Transformed and expanded in the last ed

Goodman and Gilman s The Pharmacological Basis of Therapeutics Twelfth Edition

Author: Laurence Brunton
Publisher: McGraw Hill Professional
ISBN: 0071624422
Format: PDF, Mobi
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The landmark text in medical pharmacology is now in full color Includes DVD with image bank A Doody's Core Title ESSENTIAL PURCHASE for 2011! 4 STAR DOODY'S REVIEW! "This 12th edition of the most authoritative book in pharmacology is the best both in content and physical appearance....This edition of Goodman & Gilman's continues to be the most authoritative and widely used resource bridging the discipline of pharmacology with therapeutics. Moreover, readers will find this edition to be substantially improved from past editions in both content and physical appearance."--Doody's Review Service The most universally respected and read medical text in all of pharmacology, Goodman & Gilman’s The Pharmacological Basis of Therapeutics represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman’s careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease. Enriched by a new full-color presentation and updated to reflect all critical new developments in drug action and drug-disease interaction, the twelfth edition includes more than 440 color illustrations depicting key principles and actions of specific pathways and therapeutic agents. The companion DVD includes all the images and tables in the text along with narrated animations. Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12e is divided into nine sections, covering: General Principles Neuropharmacology Modulation of Cardiovascular Function Inflammation, Immunomodulation, and Hematopoiesis Endocrine Pharmacology Gastrointestinal Pharmacology Chemotherapy of Infectious Disease Chemotherapy of Neoplastic Diseases Special Systems Pharmacology More than a textbook, Goodman & Gilman's is a working template for the effective and rational prescribing of drugs in daily practice.