Voltage Gated Sodium Channels

Author: Peter C. Ruben
Publisher: Springer Science & Business Media
ISBN: 3642415881
Format: PDF, ePub
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A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Voltage Gated Sodium Channels

Author: Peter Ruben
Publisher: Springer
ISBN: 9783642415876
Format: PDF, ePub
Download Now
A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Voltage gated Sodium Channels Structure Function and Channelopathies

Author: Mohamed Chahine
Publisher: Springer
ISBN: 3319902849
Format: PDF
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This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.

Na Channels from Phyla to Function

Author:
Publisher: Academic Press
ISBN: 012809253X
Format: PDF
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Na Channels from Phyla to Function, the latest volume in the Current Topics in Membranes series, is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up-to-date presentation of the current knowledge in the field of Na Channels. Written by leading experts in the field of Na Channels Contains original material, both textual and illustrative, that make it a very relevant reference Presented in a very comprehensive manner Both researchers in the field and general readers will find this book relevant and up-to-date with regard to its information

Allgemeine und spezielle Pharmakologie und Toxikologie

Author: Klaus Aktories
Publisher: Elsevier Health Sciences
ISBN: 3437172123
Format: PDF
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Wer mit „Aktories" lernt, versteht Das gesamte Wissen der Pharmakologie und Toxikologie ist so verständlich und anschaulich erklärt, dass man seit Jahrzehnten auf dieses Standardwerk schwört. Mit über 1200 Seiten, rund 800 Abbildungen und 300 Tabellen ist diese 12. Auflage auf dem neuesten Stand der Wissenschaft: Arzneimittelwirkungen im Gesamtzusammenhang begreifen: Wirkmechanismen und pathophysiologische Bezüge in jedem Kapitel Zusammenhänge verstehen: Ausführliches Kapitel zur allgemeinen Pharmakologie und Toxikologie erleichtert das Verständnis der speziellen pharmakologischen Zusammenhänge Praktische Relevanz: Empfehlungen zu Therapie und Dosierungen in farbig hervorgehobenen Kästen Der „Aktories" – bewährt als erstklassiges Lehrbuch für Medizinstudenten, begehrt als Nachschlagewerk für Ärzte, Pharmakologen und Pharmazeuten.

Principles and Practice of Regional Anaesthesia

Author: Graeme McLeod
Publisher: Oxford University Press
ISBN: 0199586691
Format: PDF, Docs
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The fourth edition of this highly successful textbook discusses the practical applications of the various methods of regional anaesthesia, including ultrasound, as well as giving an account of their theoretical aspects. The well-established author team use their experience to provide a practical and stimulating book which reflects everyday clinical activity, supplemented by high definition ultrasound images and schematic diagrams. The book will also discuss the place of regional anaesthesia in current medical practice, particularly with regard to pain processes, ultrasound imaging, and patient outcomes. Regional anaesthesia is a rapidly expanding sub-speciality of anaesthesia: routine provision of long-lasting pain relief and the introduction of real-time ultrasound block has fuelled a demand for cadaver and ultrasound-based anatomy training courses. Thus, it is more important than ever to have a thorough grounding in this exciting subspecialty.

Voltage Gated Sodium Channels

Author: Mohamed Chahine
Publisher: Springer
ISBN: 9783030079826
Format: PDF, ePub, Mobi
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This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.

Pharmacology and Therapeutics for Dentistry E Book

Author: John A. Yagiela
Publisher: Elsevier Health Sciences
ISBN: 0323078249
Format: PDF, ePub, Docs
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Use your knowledge of pharmacology to enhance oral care! Pharmacology and Therapeutics for Dentistry, 6th Edition describes how to evaluate a patient’s health and optimize dental treatment by factoring in the drugs they take. It explores the basic fundamentals of pharmacology, special topics such as pain control, fear and anxiety, and oral complications of cancer therapy, and most importantly, the actions of specific drug groups on the human body. Whether you’re concerned about the drugs a patient is already taking or the drugs you prescribe for treatment, this book helps you reduce risk and provide effective dental care. An emphasis on the dental applications of pharmacology relates drugs to dental considerations in clinical practice. Dental aspects of many drug classes are expanded to include antibiotics, analgesics, and anesthetics. The Alternative Medicine in Dentistry chapter discusses chemicals used as alternative medicines and assesses their potential benefits and risks. The Nonopioid Analgesics chapter groups together non-opioid analgesics, nonsterioidal anti-inflammatory drugs, and antirheumatic and antigout drugs, making these easier to locate and study. Coverage of the endocrine system includes four separate chapters for the most comprehensive coverage. Drug Interactions in Clinical Dentistry appendix lists potential interactions between drugs a patient is taking for nondental conditions and drugs that may be used or prescribed during dental treatment, including effects and recommendations. Glossary of Abbreviations appendix includes the most common abbreviations used for drugs or conditions. New Pharmacogenetics and Pharmacogenomics chapter covers the effects of genetic traits of patients on their responses to drugs. A NEW introductory section offers tips for the study of dental pharmacology and relates pharmacology to dental considerations. An updated discussion of drug-drug interactions covers the harmful effects of mixing medications. Coverage of adverse effects and mechanisms of COX-2 inhibitors, antibiotic prophylaxis, and antiplaque agents explains the dental risks relating to common drug treatments.

Goodman and Gilman s The Pharmacological Basis of Therapeutics 13th Edition

Author: Laurence Brunton
Publisher: McGraw Hill Professional
ISBN: 1259584747
Format: PDF
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The gold-standard of pharmacology texts – completely updated to reflect the latest research and developments Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, Thirteenth Edition represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman’s careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease. The Thirteenth Edition includes more than 500 color illustrations, with many new figures emphasizing mechanisms of drug action. More than 30 new contributors have added to this edition, while the focus on basic principles is undiminished. This edition is enhanced by timely new content: •NEW chapters including Treatment of Pulmonary Arterial Hypertension, Immunity and Inflammation, Immunoglobulins and Vaccines, and Treatment of Viral Hepatitis •Expanded coverage of cardiovascular disease, with separate chapters on myocardial ischemia, hypertension, and heart failure •Increased emphasis on cellular signaling pathways involved in drug action •Summary tables at the end of each chapter that organize drugs discussed in that chapter into relevant categories and detail therapeutic usage, clinical pharmacology, and tips •Chapter Content Outlines at the beginning of each chapter •Abbreviation boxes in every chapter to easily identify the abbreviations appearing in that chapter More than a textbook, Goodman & Gilman’s is a working template for the effective and rational prescribing of drugs in daily practice.

Goodman Gilman s the Pharmacological Basis of Therapeutics

Author: Louis Sanford Goodman
Publisher: McGraw-Hill Companies
ISBN:
Format: PDF, Docs
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For more than fifty years, scientists, clinicians, & students have relied on "Goodman & Gilman for the final word on the pharmacokinetics, mechanisms of action & therapeutic application of drugs. This edition sustains that proud tradition & infuses the latest information on molecular pharmacology as it redefines the definite database of pharmacologic therapeutics. As a course text or a daily reference in clinical practice, "G & G" offers the optimal mix of basic science & clinical coverage as it pertains to effective drug therapy.