Zika Virus and Diseases

Author: Suzane R. da Silva
Publisher: John Wiley & Sons
ISBN: 1119408644
Format: PDF, ePub, Docs
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Zika virus (ZIKV) is a flavivirus discovered in 1947 at the Zika forest, Uganda. Between 1952 and 1988 approximately 30 papers were published about Zika demonstrating that this virus caused mild symptoms in humans and monkeys, but could be lethal for mice. Since there was no significant disease documented in humans, just a few papers had been published before 2014. This scenario changed in 2013-2014, with an outbreak well-documented in French Polynesia, and this time there was association with the Guillain-Barr� syndrome. Shortly after that, in the beginning of 2015, the virus was detected in Brazil for the first time, and by the end of 2015 it was suggested that it was associated with the innumerous cases of microcephaly in newborns in Brazil. In February 2016, the World Health Organization (WHO) declared Zika infection as a Public Health Emergency of International Concern. Since then, more than one thousand papers have been published. The animal models have demonstrated the association between Zika virus and microcephaly, and the in vitro experimental results published up to this date are focusing on understanding a few questions: how Zika virus infects the cells, which cells are the targets, the differences between the strains (African and Asian), how the immune system respond to the infection, drug screening and possible pathways, which could be targeted to eliminate the virus, and understanding the modes of transmission, especially the mother-fetus transmission. All these studies came to some answers to these questions, but in the same time, generated new questions. Special attention for the general community is the sexual transmitted nature, now a well-described mode of transmission. Zika virus is primarily transmitted by mosquitos Aedes. ssp (mainly Aedes aegypti and Aedes albopictus) and it has been documented that in this summer the virus have reached Florida. The main goal of this book is to provide the most up-to-date information for students, medical students and scientists on Zika virus and its associated diseases. This book will include all the information related to Zika virus since its discovery in 1947, its epidemic outbreak in 2007-2014, how the epidemiology changed in America in 2015-2016, mode of transmission, prevention, and treatment of Zika virus infection and associated diseases. Within the last 8 months, the scientific community has received more than one thousand papers published on PubMed. This makes it difficult to keep track of everything that is newly discovered, making this book a comprehensive source of information on the topic.

ZIKA VIRUS DISEASE

Author: Adnan Quereshi
Publisher: Academic Press
ISBN: 0128125470
Format: PDF, Docs
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Zika Virus provides an authoritative account of one of most fascinating viruses of the 21st century, covering all the main points. It includes coverage of clinical manifestations, such as fever and fatigue, but also delves into neurological manifestations like acute demyelinating neuropathy. In addition, the book discusses new evidence that suggests that Zika fever in pregnant women can cause abnormal brain development in fetuses by mother-to-child transmission. The Zika virus infection has become one of the first where women are actively discouraged from getting pregnant. Readers will find this book to be a comprehensive resource on the topic. Covers every important aspect of the Zika virus disease, from biological, to social and economic impacts Focuses on women’s health issues that have surfaced, including birth defects in newborns Written in an easy to comprehend manner, with technical terms clearly defined in chapters that highlight genetics

Ecology and Evolution of Infectious Diseases

Author: Benjamin Roche
Publisher: Oxford University Press
ISBN: 0192507109
Format: PDF, ePub
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In recent years, the ecology and evolution of infectious diseases has been studied extensively and new approaches to the study of host-pathogen interactions continue to emerge. At the same time, pathogen control in low-income countries has tended to remain largely informed by classical epidemiology, where the objective is to treat as many people as possible, despite recent research suggesting new opportunities for improved disease control in the context of limited economic resources. The need to integrate the scientific developments in the ecology and evolution of infectious diseases with public health strategy in low-income countries is now more important than ever. This novel text uniquely incorporates the latest research in ecology and evolutionary biology into the discussion of public health issues in low-income countries. It brings together an international team of experts from both universities and health NGOs to provide an up-to-date, authoritative, and challenging review of the ecology and evolution of infectious diseases, focusing on low-income countries for effective public health applications and outcomes. It discusses a range of public health threats including malaria, TB, HIV, measles, Ebola, tuberculosis, influenza and meningitis among others.

New Advances on Zika Virus Research

Author: Luis Martinez-Sobrido
Publisher: MDPI
ISBN: 3038977640
Format: PDF, ePub
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Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family that historically has been associated with mild febrile illness. However, the recent outbreaks in Brazil in 2015 and its rapid spread throughout South and Central America and the Caribbean, together with its association with severe neurological disorders—including fetal microcephaly and Guillain-Barré syndrome in adults—have changed the historic perspective of ZIKV. Currently, ZIKV is considered an important public health concern that has the potential to affect millions of people worldwide. The significance of ZIKV in human health and the lack of approved vaccines and/or antiviral drugs to combat ZIKV infection have triggered a global effort to develop effective countermeasures to prevent and/or treat ZIKV infection. In this Special Issue of Viruses, we have assembled a collection of 32 research and review articles that cover the more recent advances on ZIKV molecular biology, replication and transmission, virus–host interactions, pathogenesis, epidemiology, vaccine development, antivirals, and viral diagnosis.

Understanding Viruses

Author: Teri Shors
Publisher: Jones & Bartlett Publishers
ISBN: 0763785539
Format: PDF, Kindle
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The Second Edition of Understanding Viruses provides a balanced approach to this fascinating discipline, combining the molecular, clinical, and historical aspects of virology. Updated throughout to keep pace with this fast-paced field, the text provides a strong, comprehensive introduction to human viral diseases. New material on molecular virology as well as new virus families presented coupled with chapters on viral diseases of animals; the history of clinical trials, gene therapy, and xenotransplantation; prions and viroids; plant viruses; and bacteriophages add to the scope of the text. Chapters discussing specific viral diseases weave in an epidemiological and global perspective and include treatment and prevention information. Contemporary case studies, Refresher Boxes, and Virus Files engage students in the learning process. Important Notice: The digital edition of this book is missing some of the images or content found in the physical edition.

Understanding Viruses

Author: Teri Shors
Publisher: Jones & Bartlett Publishers
ISBN: 1449675883
Format: PDF, ePub, Docs
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The ideal text for undergraduate students majoring in biology, microbiology, medical technology, or pre-med, the Second Edition of Understanding Viruses provides a balanced approach to this fascinating discipline, combining the molecular, clinical, and historical aspects of virology. Updated throughout to keep pace with this fast-paced field, the text provides a strong, comprehensive introduction to human viral diseases. New material on molecular virology as well as new virus families presented coupled with chapters on viral diseases of animals; the history of clinical trials, gene therapy, and xenotranplantation; prions and viroids; plant viruses; and bacteriophages add to the scope of the text. Chapters discussing specific viral diseases weave in an epidemiological and global perspective and include treatment and prevention information. Contemporary case studies, Refresher Boxes, and Virus Files engage students in the learning process. With a wealth of student and instructor support tools, Understanding Viruses is an accessible, exciting, and engaging text for your virology course.

Molecular Detection of Human Viral Pathogens

Author: Dongyou Liu
Publisher: CRC Press
ISBN: 1439812373
Format: PDF
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Despite being recognized and fought against over countless centuries, human viral pathogens continue to cause major public health problems worldwide—killing millions of people and costing billions of dollars in medical care and lost productivity each year. With contributions from specialists in their respective areas of viral pathogen research, Molecular Detection of Human Viral Pathogens provides a reliable reference on molecular detection and identification of major human viral pathogens. Each chapter briefly reviews the classification, epidemiology, clinical features, and diagnosis of one related viral pathogen or a group of them. The clinical sample collection and preparation procedures are outlined, and a selection of representative stepwise molecular detection protocols is covered. The chapters conclude with a discussion on further research requirements relating to improved diagnosis. With its judicious selection of streamlined, ready-to-use protocols for major human viral pathogens—including commercial kits—Molecular Detection of Human Viral Pathogens is an indispensable tool for medical, veterinary, and industrial laboratory scientists involved in virus determination.

Zika The Emerging Epidemic

Author: Donald G. McNeil
Publisher: W. W. Norton & Company
ISBN: 0393609170
Format: PDF
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A gripping narrative about the origins and spread of the Zika virus by New York Times science reporter Donald G. McNeil Jr. Until recently, Zika—once considered a mild disease—was hardly a cause for global panic. But as early as August 2015, doctors in northeast Brazil began to notice a trend: many mothers who had recently experienced symptoms of the Zika virus were giving birth to babies with microcephaly, a serious disorder characterized by unusually small heads and brain damage. By early 2016, Zika was making headlines as evidence mounted—and eventually confirmed—that microcephaly is caused by the virus, which can be contracted through mosquito bites or sexually transmitted. The first death on American soil, in February 2016, was confirmed in Puerto Rico in April. The first case of microcephaly in Puerto Rico was confirmed on May 13, 2016. The virus has been known to be transmitted by the Aedes aegypti or Yellow Fever mosquito, but now Aedes albopictus, the Asian Tiger mosquito, has been found to carry it as well, which means it might affect regions as far north as New England and the Great Lakes. Right now, at least 298 million people in the Americas live in areas “conducive to Zika transmission,” according to a recent study. Over the next year, more than 5 million babies will be born. In Zika: The Emerging Epidemic, Donald G. McNeil Jr. sets the facts straight in a fascinating exploration of Zika’s origins, how it’s spreading, the race for a cure, and what we can do to protect ourselves now.